PMID: 8948447Jun 15, 1995Paper

The early stimulation of glycolysis by epidermal growth factor in isolated rat hepatocytes is secondary to the glycogenolytic effect

The Biochemical Journal
I QuintanaM Soley

Abstract

We have studied the relationship between the effect of epidermal growth factor (EGF) on glycogen metabolism and its effect on glycolysis, in rat hepatocyte suspensions. Although 10 nM glucagon or 10 microM adrenaline increased glycogen degradation by more than 120%, 10 nM EGF increased glycogenolysis by less than 20% in hepatocytes incubated in glucose-free medium. Both glucagon and adrenaline increased phosphorylase a activity by more than 130%; EGF increased this activity by about 30%. Under basal conditions, 65% of the glucosyl residues were released as free glucose and about 30% ended up as C3 molecules (lactate and pyruvate). Both glucagon and adrenaline decreased the proportion of glucosyl units that rendered glycolysis end-products (to 2% for glucagon and 6% for adrenaline) and increased the proportion that ended up as free glucose (to 94% and 88% of the glucosyl residues for glucagon and adrenaline respectively). EGF increased the production of both free glucose and lactate+pyruvate, but the proportion of glucosyl residues that ended up as free glucose or glycolysis end-products was unchanged. In glycogen-depleted hepatocytes incubated in the presence of 25 mM glucose, EGF affected neither glycogen deposition nor glycol...Continue Reading

Citations

Nov 19, 2003·European Journal of Biochemistry·Irmelin ProbstPeter Bütikofer
Nov 24, 2011·Apoptosis : an International Journal on Programmed Cell Death·Sven GottschalkMarc Bilodeau
Mar 5, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A AlbalatI Navarro
Sep 18, 2002·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Xavier GalanIgnasi Ramírez
Oct 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Jordi LoritaIgnasi Ramírez
Dec 1, 1996·Cellular Signalling·M MarinoS Leoni

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