The Ebola virus glycoprotein and its immune responses across multiple vaccine platforms.

Expert Review of Vaccines
Kyle O'Donnell, Andrea Marzi

Abstract

Introduction: For over 40 years, ebolaviruses have been responsible for sporadic outbreaks of severe and often fatal hemorrhagic fever in humans and nonhuman primates across western and central Africa. In December 2013, an unprecedented Ebola virus (EBOV) epidemic began in West Africa and resulted in the largest outbreak to date. The past and current epidemics in West Africa and the Democratic Republic of the Congo has focused attention on the potential vaccine platforms developed over the past 20 years.Areas covered: This review summarizes the extraordinary progress using a variety of vaccination platforms including DNA, subunit, and several viral vector approaches, replicating and non-replicating, incorporating the primary antigen of EBOV, the glycoprotein. These vaccine constructs have shown varying degrees of protective efficacy in the 'gold-standard' nonhuman primate model for EBOV infections and were immunogenic in human clinical trials.Expert commentary: A number of these vaccine platforms have moved into phase III clinical trials over the past years and with the recent approval of the first EBOV vaccine in the European Union and the USA there is a strong potential to prevent future outbreaks/epidemics of EBOV infections...Continue Reading

References

May 1, 1986·The Journal of Pediatrics·F W Denny, W A Clyde
Dec 13, 1980·Lancet·A AbonstamZ Hamad
Apr 10, 1999·Journal of Virology·A RobertsJ K Rose
May 9, 2002·Emerging Infectious Diseases·Thomas W GeisbertPeter B Jahrling
Dec 4, 2002·Tropical Medicine & International Health : TM & IH·S I OkwareM Lamunu
Apr 8, 2003·Nature·Peter D WalshDavid S Wilkie
Oct 29, 2003·Journal of Virology·Albert A RizvanovStephen C St Jeor
Jun 24, 2005·PLoS Medicine·Thomas W GeisbertHeinz Feldmann
Dec 17, 2005·Virology·Gary P KobingerJames M Wilson
Aug 9, 2006·The Journal of General Virology·Soumitra RoyJames M Wilson
Sep 26, 2006·Methods : a Companion to Methods in Enzymology·Deborah H FullerConnie Schmaljohn
Apr 12, 2007·The American Naturalist·Peter D WalshDiane Doran-Sheehy
Dec 6, 2007·The Journal of Infectious Diseases·Kelly L WarfieldSina Bavari
Jan 24, 2008·Proceedings of the National Academy of Sciences of the United States of America·Peter HalfmannYoshihiro Kawaoka
Jan 25, 2008·Clinical and Vaccine Immunology : CVI·Dana L SwensonWilliam D Pratt
Feb 13, 2009·Journal of Virology·Peter HalfmannYoshihiro Kawaoka
Nov 19, 2010·Lancet·Heinz Feldmann, Thomas W Geisbert
Jan 18, 2011·Biologicals : Journal of the International Association of Biological Standardization·Ingo JordanVolker Sandig
Mar 18, 2011·Journal of Virology·Masfique MehediHeinz Feldmann
Aug 25, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Susanne H SheehySimon J Draper
Oct 19, 2011·The Journal of Infectious Diseases·Mark G KortepeterMike Bray

❮ Previous
Next ❯

Related Concepts

Related Feeds

Argentine Hemorrhagic Fever

Argentine hemorrhagic fever (AHF) is an endemo-epidemic disease caused by junín virus (JUNV), a member of the arenaviridae family. Discover the latest research on AHF here.