The ecdysone-inducible Broad-complex and E74 early genes interact to regulate target gene transcription and Drosophila metamorphosis.

Genetics
J C Fletcher, C S Thummel

Abstract

Pulses of the steroid hormone ecdysone initiate Drosophila metamorphosis by inducing widespread changes in gene expression. The Broad-Complex (BR-C) and E74 are induced directly by ecdysone and encode families of transcription factors that regulate ecdysone primary- and secondary-response genes. Genetic analyses have revealed that mutations in the BR-C and E74 are lethal during metamorphosis and that these mutations cause some similar lethal phenotypes and alterations in secondary-response gene transcription. To examine whether the BR-C and E74 function together during development, we have combined representative alleles from each BR-C and E74 complementation group. Analysis of the morphological and molecular phenotypes of the double-mutant animals reveals that BR-C and E74 alleles act together to produce both novel and synergistic effects. We find that the BR-C and E74 share functions in puparium formation, pupation and early gene induction. In addition, our evidence suggests that the BR-C and E74 transcription factors may directly interact to regulate the expression of salivary gland glue and late genes. This data is consistent with current models which propose that combinations of ecdysone primary-response genes regulate com...Continue Reading

Citations

Nov 4, 2006·Genesis : the Journal of Genetics and Development·L R BassoM L Paçó-Larson
May 3, 2006·The Journal of Experimental Biology·Sebastien A Gauthier, Randall S Hewes
Apr 24, 2002·Developmental Biology·Jonathan C DunneCatherine Rabouille
Jan 1, 1996·Archives of Insect Biochemistry and Physiology·E H Baehrecke
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·J C FletcherC S Thummel
Jan 4, 2001·Cell Death and Differentiation·E H Baehrecke
Apr 28, 2016·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Dongyu JiaWu-Min Deng
Jul 12, 2002·Insect Biochemistry and Molecular Biology·Sushmita MaitraRanjan Ganguly
Jan 27, 2010·Genetics·Dongmei Liu, Russell L Finley
Feb 14, 2009·PLoS Genetics·Suganthi ChittaranjanSharon M Gorski
Jul 14, 2010·Developmental Biology·Yanhui XiangXun Huang
Aug 12, 2010·Fly·Dongmei LiuRussell L Finley
Feb 25, 2009·Genome Research·Zareen GauharKevin P White

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