The ECM path of senescence in aging: components and modifiers.

The FEBS Journal
Naama LeviValery Krizhanovsky

Abstract

The extracellular matrix (ECM) is a key noncellular component in all organs and tissues. It is composed of a large number of proteins including collagens, glycoproteins (GP), and ECM-associated proteins, which show diversity of biochemical and biophysical functions. The ECM is dynamic both in normal physiology of tissues and under pathological conditions. One cellular phenomenon associated with changes in both ECM components expression and in ECM remodeling enzymes secretion is cellular senescence. It represents a stable state form of cell cycle arrest induced in proliferating cells by various forms of stress. Short-term induction of senescence is essential for tumor suppression and tissue repair. However, long-term presence of senescent cells in tissues may have a detrimental role in promoting tissue damage and aging. Up to date, there is insufficient knowledge about the interplay between the ECM and senescence cells. Since changes in the ECM occur in many physiological and pathological conditions in which senescent cells are present, a better understanding of ECM-senescence interactions is necessary. Here, we will review the functions of the different ECM components and will discuss the current knowledge about their regulatio...Continue Reading

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Citations

Oct 22, 2020·Clinical Science·Kaj E C BloklandJanette K Burgess
Jan 16, 2021·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Kei Shing OhRobert Poppiti
Oct 15, 2020·International Journal of Molecular Sciences·Ruben Aquino-MartinezDavid G Monroe
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May 1, 2021·International Journal of Molecular Sciences·Eleanor K Greenwood, David R Brown
May 11, 2021·Frontiers in Oncology·Yunchun ZhaoCaihong Zheng
Jun 3, 2021·Pharmaceuticals·Young-Dan ChoYang-Jo Seol
Jun 29, 2021·Frontiers in Physiology·Evanthia A Makrygianni, George P Chrousos
Jul 1, 2021·Critical Reviews in Biotechnology·Amanda Marchini, Fabrizio Gelain
Aug 6, 2021·Mechanisms of Ageing and Development·Julia Majewska, Valery Krizhanovsky
Aug 12, 2021·Npj Regenerative Medicine·Rita N GomesDiana S Nascimento
Aug 31, 2021·International Journal of Cancer. Journal International Du Cancer·Debmita Chatterjee, Oishee Chakrabarti

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