The economic analyses of the UK prospective diabetes study

Diabetic Medicine : a Journal of the British Diabetic Association
A M Gray, P Clarke

Abstract

An economic analysis was not initially included in the study design of the UK Prospective Diabetes Study (UKPDS). However, data were collected throughout the study on hospital drugs and medications used and these were supplemented near the end of the study by cross-sectional surveys of non-inpatient healthcare use and quality of life. Evaluations of tight vs. less tight blood pressure control, intensive vs. less conventional blood glucose control and metformin showed that each was highly cost-effective and that all could be provided at modest total cost. Further analyses showed that amputations and stroke had particularly severe consequences for quality of life, and that amputations and non-fatal MI had high cost consequences. Finally, patient-level data were used to construct a diabetes outcomes model, which estimates the probability of longer-term complications from patient-specific risk factors and can be used in populations at different stages of diabetes progression. The economic analyses arising from the UKPDS have provided new evidence to clinicians, policymakers and researchers on the consequences of diabetes and the cost-effectiveness of interventions, thereby assisting the development of treatment guidelines and impro...Continue Reading

References

Sep 1, 1994·Health Economics·B A van HoutF F Rutten
Aug 6, 1998·The New England Journal of Medicine·J C Wright, M C Weinstein
Feb 9, 1986·Journal of Health Economics·G W Torrance
Nov 18, 2000·Diabetes Research and Clinical Practice·R StevensR Holman
Apr 25, 2001·Diabetologia·P ClarkeUNKNOWN UKPDS Group. United Kingdom Prospective Diabetes Study
Jul 27, 2001·Diabetic Medicine : a Journal of the British Diabetic Association·A GrayUNKNOWN UKPDS Group
Aug 2, 2002·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Philip ClarkeRury Holman
Oct 19, 2002·BMJ : British Medical Journal·Alastair GrayUNKNOWN United Kingdom Prospective Diabetes Study (UKPDS) Group
Aug 31, 2004·Diabetes Care·UNKNOWN American Diabetes Association Consensus Panel
Apr 19, 2005·Diabetologia·P M ClarkeUNKNOWN UKPDS 72 United Kingdom Prospective Diabetes Study
Jan 10, 2006·Lancet·Pierre-Jean Guillausseau
Jan 10, 2006·Lancet·R R HolmanR Stevens

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Citations

Oct 7, 2011·Cost Effectiveness and Resource Allocation : C/E·Talitha L FeenstraCaroline A Baan
Jul 21, 2010·Current Medical Research and Opinion·Y YiK Burslem
Feb 17, 2009·Diabetes/metabolism Research and Reviews

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