The Economic Burden of ACPA-Positive Status Among Patients with Rheumatoid Arthritis

Journal of Managed Care & Specialty Pharmacy
Jason ShafrinKaleb Michaud

Abstract

Anticitrullinated protein antibodies (ACPAs) are serological biomarkers associated with early, rapidly progressing rheumatoid arthritis (RA), including more severe disease and joint damage. ACPA testing has become a routine tool for RA diagnosis and prognosis. Furthermore, treatment efficacy has been shown to vary by ACPA-positive status. However, it is not clear if the economic burden of patients with RA varies by ACPA status. To determine if the economic burden of RA varies by patient ACPA status. IMS PharMetrics Plus health insurance claims and electronic medical record (EMR) data from 2010-2015 were used to identify patients with incident RA. Patients were aged ≥ 18 years, had ≥ 1 inpatient or ≥ 2 outpatient claims reporting an RA diagnosis code (ICD-9-CM code 714.0), and had an anticyclic citrullinated peptide (anti-CCP; a surrogate of ACPA) antibody test within 6 months of diagnosis. Incident patients were defined as those who had no claims with an RA diagnosis code in the 6 months before the first observed RA diagnosis. The primary outcome of interest was RA-related medical expenditures, defined as the sum of payer- and patient-paid amounts for all claims with an RA diagnosis code. Secondary outcomes included health care...Continue Reading

References

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Jan 1, 2008·Arthritis and Rheumatism·Charles G HelmickUNKNOWN National Arthritis Data Workgroup
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Sep 3, 2013·International Journal of Rheumatic Diseases·Sima Sh FaridAbbas Mirshafiey

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Citations

Jun 22, 2018·Journal of Toxicology and Environmental Health. Part a·Roger DiegelRaja Flores
Mar 28, 2019·Journal of Managed Care & Specialty Pharmacy·JaeJin AnT Craig Cheetham
Jul 16, 2021·Therapeutic Advances in Musculoskeletal Disease·Hyoungyoung KimYoon-Kyoung Sung

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