The economic impact of depression: resistance or severity?

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
L FostickD Amital

Abstract

Treatment-Resistant Depression (TRD) affects 60 to 70% of patients with Major Depressive Disorder (MDD). The economic impact of depression in general, and of TRD specifically, was found to be relatively high. As the course of depression can be defined both by the severity of the disease and by the resistance to treatment, the question of the unique contribution of MDD severity vs. resistance to the economic burden of depression is being raised. One hundred and seven unipolar MDD patients, all treated for at least 4weeks, were enrolled in the study. Patients were assessed for their current MDD severity using the Hamilton Depression Rating Scale (HDRS) and past treatments, and for medical-related costs (number of blood and imaging tests, visits paid to physicians, psychiatric hospitalizations) and incapacity-related costs (number of working days lost) during the last episode. TRD and non-TRD patients were, respectively, 39.3% and 60.7% of the patients recruited for the study. TRD patients had more severe depression, and higher costs for imaging tests, physician visits, psychiatric hospitalizations, and number of working days lost. In addition, higher MDD severity was found to be associated with higher costs. Finally, when control...Continue Reading

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Citations

Nov 6, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·D AmitalJ Zohar
Jan 18, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Claudia SchmuckermairNicolas Singewald
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Jul 20, 2013·Journal of Affective Disorders·Mauro Garcia-ToroCarlos Blanco
Oct 16, 2014·Journal of Psychopharmacology·Roger M Lane
Nov 5, 2015·Behavioural and Cognitive Psychotherapy·Alex BurrageGlyn Lewis
Dec 26, 2017·Journal of Mental Health·Paul McCronePeter Fonagy
Feb 15, 2019·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Sage BrownFiona Clement
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Dec 5, 2020·Journal of Psychiatric Practice·Thekiso B ThekisoNoel Kennedy

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