PMID: 9635493Jul 11, 1998Paper

The ecotoxicological significance of genotoxicity in marine invertebrates

Mutation Research
M H Depledge

Abstract

Attention is drawn to the goals of genetic ecotoxicology, in particular, the need to relate genotoxicity in individuals to population and community level consequences. The evidence for pollutant-induced genotoxicity in marine invertebrates is reviewed. Neoplasia is apparently rare in marine invertebrates and only limited evidence is available to suggest that chemical genotoxins act as causative agents. It is unknown why marine invertebrates exhibit low tumour incidences and are much more tolerant of ionising radiation than their vertebrate counterparts. The importance of the genotoxic disease syndrome is highlighted. Disentangling phenotypic manifestations of genotoxic damage and that due to direct metabolic toxicity provides a major challenge for the future. Further work is required to assess the significance of interspecific and interindividual variability in susceptibility to genotoxicity, especially with regard to the evolution of resistant populations and communities of marine organisms at contaminated sites. Only by addressing the issues highlighted above can proper risk assessments of genotoxic agents be performed to minimise threats to human and ecosystem health.

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Citations

Feb 10, 2009·Ecotoxicology·Anamaria StambukGöran I V Klobucar
Dec 7, 2002·Toxicon : Official Journal of the International Society on Toxinology·C R Carvalho Pinto-SilvaW G Matias
Oct 12, 2001·Aquatic Toxicology·H DizerP D Hansen
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Aug 12, 2015·Aquatic Toxicology·Neil FullerAlex T Ford
May 30, 2012·Aquatic Toxicology·Ceri Lewis, Alex T Ford
Aug 27, 2011·Journal of Hazardous Materials·Barbara DmochowskaGrzegorz Węgrzyn
Jun 27, 2008·Mutation Research·Ceri Lewis, Tamara Galloway
Dec 2, 2004·Mutation Research·Takeshi OheKeiji Wakabayashi
Dec 2, 2004·Mutation Research·Guosheng Chen, Paul A White
Jan 28, 2006·The Science of the Total Environment·Nevenka BihariBlanka Kralj-Bilen
Aug 15, 2006·The Journal of Animal Ecology·Elske M De HaasWim Admiraal
Feb 13, 2003·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Filipe O CostaLee R Shugart
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Jan 5, 2012·Radiation Research·Lorna J DallasAwadhesh N Jha
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Apr 5, 2012·Journal of Ethnopharmacology·Upendra SharmaSupriya Bhalerao

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