PMID: 15227962Jul 2, 2004Paper

The ectopic ACTH syndrome

Srpski arhiv za celokupno lekarstvo
Zorana PenezićMilka Drezgićc

Abstract

Endogenous Cushing's syndrome is a clinical state resulting from prolonged, inappropriate exposure to excessive endogenous secretion of cortisol and hence excess circulating free cortisol, characterized by loss of the normal feedback mechanisms of the hypothalamo-pituitary-adrenal axis and the normal circadian rhythm of cortisol secretion [2]. The etiology of Cushing's syndrome may be excessive ACTH secretion from the pituitary gland, ectopic ACTH secretion by nonpituitary tumor, or excessive autonomous secretion of cortisol from a hyperfunctioning adrenal adenoma or carcinoma. Other than this broad ACTH-dependent and ACTH-independent categories, the syndrome may be caused by ectopic CRH secretion, PPNAD, MAH, ectopic action of GIP or catecholamines, and other adrenel-dependent processes associated with adrenocortical hyperfunction. A 31 year-old men with 6-month history of hyperpigmentation, weight gain and proximal myopathy was refereed to Institute of Endocrinology for evaluation of hypercortisolism. At admission, patient had classic cushingold habit with plethoric face, dermal and muscle atrophy, abdominal strie rubrae and centripetal obesity. The standard laboratory data showed hyperglycaemia and hypokaliemia with high pot...Continue Reading

References

Sep 26, 1997·The Journal of Thoracic and Cardiovascular Surgery·J B ShragerD J Mathisen
Sep 24, 1998·The New England Journal of Medicine·E AriogluD A Papanicolaou
Mar 18, 1999·The New England Journal of Medicine·M H Kulke, R J Mayer
Mar 20, 2001·Lancet·M BoscaroN Sonino

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Citations

May 16, 2020·Frontiers in Oncology·Valentina Di RuscioAngela Mastronuzzi
Aug 30, 2019·Khirurgiia·V V KrylovV V Levkin
Apr 3, 2008·Proceedings·Poorya FazelNed A Austin

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