The ECVAM international validation study on in vitro tests for acute skin irritation: selection of test chemicals

Alternatives to Laboratory Animals : ATLA
Chantra EskesValérie Zuang

Abstract

The ECVAM-funded skin irritation validation study (SIVS) was initiated in 2003, with the aim to evaluate whether the EpiDerm, EPISKIN and the SIFT alternative methods were able to reliably identify skin irritant and non-irritant chemicals, and could therefore be candidates for replacing the rabbit Draize test for skin irritation. The primary goal of the study was to evaluate the predictive capacity of the assays with regard to the EU classification system, which employs the risk phrases, "R38", for skin irritants, and "no label" for non-irritants. A secondary objective was the retrospective analysis of the data, to assess whether the in vitro tests would be able to discriminate between strong irritants (category 2), mild irritants (category 3) and non-irritants (no category), as defined by the OECD and United Nations proposal for a Globally Harmonised System (GHS) for the classification and labelling of dermal irritancy. A Chemicals Selection Sub-Committee (CSSC) was appointed to identify test chemicals to be used in the SIVS, for which existing, high quality in vivo data were available, with which to correlate the in vitro measurements. Since chemicals from the European Centre for the Ecotoxicology and Toxicology of Chemicals ...Continue Reading

References

Mar 26, 2003·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J R HeylingsH M Owen
Mar 8, 2005·Regulatory Toxicology and Pharmacology : RTP·Sebastian HoffmannThomas Hartung
Jun 17, 2005·Human & Experimental Toxicology·Philip S GuzelianChristopher P Guzelian
Jul 16, 2005·Journal of Clinical Epidemiology·Antoine FlahaultGuy Thomas
Oct 5, 2006·Human & Experimental Toxicology·S Hoffmann, T Hartung

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Citations

Jun 5, 2020·Alternatives to Laboratory Animals : ATLA·Samara EberlinAdriano da Silva Pinheiro
Jul 1, 2009·International Journal of Cosmetic Science·A T Grazul-BilskaA Abdullah
Dec 5, 2012·The Journal of Toxicological Sciences·Tomoyasu ToyoizumiKohji Yamakage
Dec 9, 2008·SAR and QSAR in Environmental Research·M Pavan, A P Worth
Sep 8, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Nathalie AlépéeAnne de Brugerolle de Fraissinette
Jan 19, 2011·Advanced Drug Delivery Reviews·Florian GroeberKatja Schenke-Layland

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