The EF-hand Ca(2+)-binding protein super-family: a genome-wide analysis of gene expression patterns in the adult mouse brain

Neuroscience
F GirardM R Celio

Abstract

In mice, 249 putative members of the superfamily of EF-hand domain Ca(2+)-binding proteins, manifesting great diversity in structure, cellular localization and functions have been identified. Three members in particular, namely, calbindin-D28K, calretinin and parvalbumin, are widely used as markers for specific neuronal subpopulations in different regions of the brain. The aim of the present study was to compile a comprehensive atlas of the gene-expression profiles of the entire EF-hand gene superfamily in the murine brain. This was achieved by a meticulous examination of the in-situ hybridization images in the Allen Brain Atlas database. Topographically, our analysis focused on the olfactory bulb, cerebral cortex (barrel cortex in the primary somatosensory area), basal ganglia, hippocampus, amygdala, thalamus, hypothalamus, cerebellum, midbrain, pons and medulla, and on clearly identifiable sub-structures within each of these areas. The expression profiles of four family-members, namely hippocalcin-like 4, neurocalcin-δ, plastin 3 and tescalcin, that have not been hitherto reported, at either the mRNA (in-situ-hybridization) or the protein (immunohistochemical) levels, are now presented for the first time. The fruit of our ana...Continue Reading

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Citations

Jul 17, 2019·Cold Spring Harbor Perspectives in Biology·Beat Schwaller
Mar 16, 2018·Oxidative Medicine and Cellular Longevity·Yeong-Min Yoo, Eui-Bae Jeung
Apr 12, 2017·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Rahul C BhoyarSaikat Biswas
Mar 12, 2019·Frontiers in Molecular Neuroscience·Aaradhita UpadhyayBrunhilde Wirth
Jan 4, 2021·Journal of Chemical Neuroanatomy·Paulo Leonardo Araújo de Góis MoraisJosé Rodolfo Lopes Paiva Cavalcanti
May 24, 2021·Cellular and Molecular Life Sciences : CMLS·Lisa WolffBrunhilde Wirth
May 2, 2020·Journal of Proteome Research·Suzy Varderidou-MinasianMaarten Altelaar

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