The EF-hand family of calcium-modulated proteins.

Trends in Neurosciences
A PersechiniR H Kretsinger

Abstract

The EF-hand homolog proteins bind calcium (Ca2+) with dissociation constants in the micromolar range and are modulated by stimulus-induced increases in cytosolic free Ca2+. We have grouped over 160 different EF-hand homolog proteins into ten subfamilies and ten unique categories. Except for troponin-C, all subfamilies and unique EF-hand homologs represented in vertebrates can be found in the CNS. In this review, structural and functional characteristics of these proteins are discussed, with special emphasis on the multifunctional regulatory protein, calmodulin. The possible function of bending within the central helix of calmodulin is considered and is illustrated with a model calmodulin--target complex.

References

Jan 1, 1989·Cell Calcium·R D Burgoyne, M J Geisow
Oct 28, 1988·Biochimica Et Biophysica Acta·L A HeppelG F Draetta
Nov 1, 1988·Trends in Biochemical Sciences·D Kligman, D C Hilt
Nov 5, 1988·Journal of Molecular Biology·Y S BabuW J Cook
Jan 1, 1987·Cold Spring Harbor Symposia on Quantitative Biology·R H Kretsinger
Jan 1, 1986·Annual Review of Biochemistry·T D Pollard, J A Cooper
Dec 30, 1987·European Journal of Biochemistry·M ParmentierG Vassart
Dec 1, 1982·Journal of Muscle Research and Cell Motility·J M GillisR H Kretsinger
Sep 24, 1981·Nature·M R Celio, C W Heizmann

❮ Previous
Next ❯

Citations

Aug 1, 1990·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A Marks, R Allore
Jul 19, 2002·Journal of Neuroscience Research·Junfeng JiSamuel Sam Wah Tay
Oct 1, 1993·Protein Science : a Publication of the Protein Society·S M PotterD W Aswad
Feb 1, 1993·Cell and Tissue Research·C AndressenM R Celio
Aug 1, 1992·Cell and Tissue Research·J G BriñónJ Aijón
Jun 10, 2006·Cellular and Molecular Neurobiology·J L IvanovaA V Belyavsky
Nov 14, 2007·Journal of Mammary Gland Biology and Neoplasia·Joshua N VanHouten, John J Wysolmerski
Dec 1, 2006·The Protein Journal·Sergei E Permyakov, Eugene A Permyakov
Jan 1, 1990·The International Journal of Biochemistry·F Schöffl, H Jockusch
Jan 14, 1994·Brain Research. Developmental Brain Research·D Hogan, N E Berman
Aug 1, 1992·Trends in Neurosciences·K G BaimbridgeJ H Rogers
Nov 10, 1992·Biochimica Et Biophysica Acta·V PohlR Pochet
Aug 1, 1996·Neuroscience Research·A ParentF Cicchetti
Apr 17, 1990·Molecular and Cellular Endocrinology·Y Salomon
Aug 14, 1992·Biochimica Et Biophysica Acta·O BachsE Carafoli
Aug 1, 1995·Neuroscience·M Rickmann, J R Wolff
Apr 1, 1996·Journal of Chemical Neuroanatomy·M FortinA Parent
Jun 6, 2006·Journal of the American Society for Mass Spectrometry·Theodore A CraigRajiv Kumar
Nov 15, 2003·Journal of Chemical Neuroanatomy·Renato F SantanaCláudio A B Toledo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.