The effect duration of candesartan cilexetil once daily, in comparison with enalapril once daily, in patients with mild to moderate hypertension

Blood Pressure
A HimmelmannEffect Study Group

Abstract

To determine the antihypertensive efficacy, effect duration and safety of the angiotensin II type 1 receptor blocker candesartan cilexetil and the angiotensin converting enzyme inhibitor enalapril once daily in patients with mild to moderate hypertension. A multicenter, randomised, double-blind parallel group study was performed in Finland, France, the Netherlands, Spain and Sweden. Three-hundred-and-ninety-five men and women in the age range 20-80 years with primary hypertension were randomised to an 8-week double-blind treatment period with either candesartan cilexetil 8-16 mg or enalapril 10-20 mg once daily, with forced dose titration after 4 weeks. Non-invasive ambulatory blood pressure was measured for 36 h at baseline and after 8 weeks. The primary efficacy variable was the change in mean diastolic and systolic ambulatory blood pressure 22-24 h post-dose. There was a significant difference in the adjusted mean difference for the change from baseline to week 8 between candesartan cilexetil and enalapril 22-24 h post-dose by -3.5 mmHg (95% confidence interval, CI: -6.8 to -0.3 mmHg; p < 0.032) in ambulatory systolic blood pressure and -3.0 mmHg (95% CI: -5.1 to -0.8 mmHg; p < 0.008) in ambulatory diastolic blood pressure. ...Continue Reading

Citations

Aug 19, 2011·Expert Opinion on Drug Safety·Vivencio Barrios, Carlos Escobar
Jun 23, 2005·Current Medical Research and Opinion·Gerd Bönner, Winfried Fuchs
Apr 24, 2012·The American Journal of Cardiology·Harikrishna MakaniSripal Bangalore
Nov 23, 2012·Expert Opinion on Pharmacotherapy·Amedeo Mugellini, Valentina Nieswandt
Aug 18, 2006·Cardiovascular Drugs and Therapy·Aldo P Maggioni
May 16, 2002·Drugs·Stephanie E Easthope, Blair Jarvis
Sep 18, 2007·Expert Review of Cardiovascular Therapy·Vivencio BarriosAlberto Calderon
Sep 1, 2011·Expert Review of Cardiovascular Therapy·Zeeshan Khawaja, Christopher S Wilcox
Dec 14, 2004·Cardiovascular Drug Reviews·Christoph H GleiterKlaus Mörike

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.