PMID: 108748Mar 29, 1979

The effect of (-) trans-delta9-tetrahydrocannabinol, alone and in combination with ethanol, on human performance

Psychopharmacology
B E BelgraveR K Teo

Abstract

Twenty five volunteers received (-) trans-delta9-tetrahydrocannabinol (THC) (320 microgram/kg) or placebo (both orally, T0), and, 60 min later, they consumed an ethanolic beverage (0.54 g/kg) or placebo. The effects of this medication were measured at T1 (100 min after THC ingestion), T2 (160 min), T3 (220 min) and T4 (280 min) using a battery of cognitive, perceptual and motor function tests. Factorial analysis indicated that the test procedures could be adequately expressed by four rotated factors: a reaction speed factor (I'), a cognitive factor (II'), a standing steadiness factor (III') and a psychomotor coordination factor (IV'). The first principal component (I) was used as a measure of general performance across the whole test battery. Both THC and ethanol produced significant decrements in the general performance factor. Ethanol produced significant decrements in standing steadiness and psychomotor coordination, while THC caused a significant deterioration in performance on all the four rotated factors. In all cases the peak effect of ethanol occurred at T1 and by T4 the effect had worn off. The performance decrements induced by THC were slower in onset and lasted longer than those induced by ethanol. In general, the pe...Continue Reading

References

Mar 1, 1976·Journal of Studies on Alcohol·H M FranksR K Teo
Sep 1, 1976·The American Journal of Psychiatry·F T Melges
Jan 1, 1973·Clinical Pharmacology and Therapeutics·M Perez-ReyesK H Davis
Jan 1, 1973·Psychopharmacologia·C F DarleyR C Atkinson
Jun 1, 1971·The British Journal of Addiction to Alcohol and Other Drugs·M KellyL Goldberg

Citations

Aug 1, 1985·Accident; Analysis and Prevention·H Moskowitz
Nov 1, 1988·Pharmacology, Biochemistry, and Behavior·S J HeishmanG E Bigelow
Sep 1, 1997·Pharmacology, Biochemistry, and Behavior·S J HeishmanM L Stitzer
Apr 21, 1983·The New England Journal of Medicine·A M Nicholi
Sep 17, 2005·Applied Psychophysiology and Biofeedback·V D CalhounG D Pearlson
Jan 1, 1996·Journal of Toxicology. Clinical Toxicology·C TomaszewskiK Kulig
Jan 1, 1992·The American Journal of Drug and Alcohol Abuse·R J CanterburyP S Westerman
Sep 12, 2015·Neurotoxicity Research·Patrycja KleczkowskaMagdalena Bujalska-Zadrozny
Apr 1, 1988·Alcoholism, Clinical and Experimental Research·M Perez-ReyesC E Cook
Jun 29, 2013·Drug and Alcohol Dependence·Yvonne M Terry-McElrathLloyd D Johnston
Dec 21, 2017·The American Journal of Drug and Alcohol Abuse·Megan E PatrickLloyd D Johnston
Sep 11, 2018·Behavioural Pharmacology·Priscilla P OomenMatthijs G Bossong
Jan 10, 2009·British Journal of Clinical Pharmacology·Lineke ZuurmanJoop M A van Gerven
Mar 25, 2010·Addiction·Jørgen G BramnessJørg Mørland
Aug 1, 1982·European Journal of Clinical Microbiology·K MachkaI Braveny
May 1, 1982·Perception & Psychophysics·H E Ross, M F Reschke
Oct 3, 2018·Alcoholism, Clinical and Experimental Research·Yvonne M Terry-McElrath, Megan E Patrick
Apr 24, 2020·Cannabis and Cannabinoid Research·Natasha E WadeKrista M Lisdahl

Related Concepts

Teens
Ethanol
Alcoholic Intoxication
Cognition
Motor Skills
Placebos
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