PMID: 698176Sep 1, 1978Paper

The effect of 1-alpha-hydroxycholecalciferol on calcium and phosphorus metabolism in the lactating ewe

The British Journal of Nutrition
G D Braithwaite

Abstract

1. The effect of 1-alpha-hydroxycholecalciferol (1 alpha-OH-D3) on calcium and phosphorus metabolism has been studied in ewes at peak lactation by a combination of a mineral balance and a radioisotope technique. 2. The rate of Ca absorption was substantially higher in the treated ewes than in controls. The rates of endogenous loss of Ca into urine, faces and milk, however, were only slightly higher. 3. In consequence, the net retention of Ca was increased and the loss of skeletal reserves of Ca normally associated with peak lactation, prevented. 4. Although the rate of bone accretion increased slightly, the increase in skeletal retention of Ca resulted mainly from a decrease in the rate of bone resorption. 5. This finding conflicts with the generally held belief that bone resorption is increased by cholecalciferol treatment. 6. The rates of apparent absorption and retention of P were increased by the treatment probably as a result of a direct effect of the 1 alpha-OH-D3 on P absorption. 7. These results provide a possible explanationof the beneficial effect of 1 alpha-OH-D3 in preventing parturient paresis (milk fever) in the dairy cow.

References

Jan 1, 1977·Advances in Clinical Chemistry·H F DeLuca
May 1, 1975·The British Journal of Nutrition·G D Braithwaite
May 1, 1974·The British Journal of Nutrition·G D Braithwaite
Oct 1, 1971·Archives of Biochemistry and Biophysics·Y Tanaka, H F Deluca
Sep 1, 1972·The British Journal of Nutrition·G D BraithwaiteS Riazuddin
Nov 1, 1969·The British Journal of Nutrition·G D BraithwaiteS Riazuddin
Sep 1, 1970·The British Journal of Nutrition·G D BraithwaiteS Riazuddin
Sep 1, 1971·The British Journal of Nutrition·G D Braithwaite, S Riazuddin
Mar 25, 1960·Biochimica Et Biophysica Acta·J P AUBERT, G MILHAUD

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Citations

Nov 1, 1983·The British Journal of Nutrition·G D Braithwaite
Sep 1, 1981·The Proceedings of the Nutrition Society·D Scott, A F McLean
Sep 14, 2001·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·B SchröderG Breves
Nov 15, 2011·The Journal of Veterinary Medical Science·Danil KimShuichi Ohashi
May 1, 1988·Journal of Dairy Science·J P GoffE T Littledike
Nov 1, 1979·The British Journal of Nutrition·J P BarletJ Lefaivre
Jul 1, 1994·Journal of Dairy Science·R L HorstT A Reinhardt

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