The effect of 12-wk ω-3 fatty acid supplementation on in vivo thalamus glutathione concentration in patients "at risk" for major depression

Nutrition
Shantel L DuffySharon L Naismith

Abstract

As life expectancy increases, the need to prevent major health disorders is clear. Depressive symptoms are common in older adults and are associated with cognitive decline and greater risk for transitioning to major depression. Oxidative stress may be implicated in the pathophysiology of major depression and can be measured in vivo using proton magnetic resonance spectroscopy via the neurometabolite glutathione (GSH). Evidence suggests ω-3 fatty acid (FA) supplementation may prevent depression and directly affect GSH concentration. The aim of this study was to examine the effect of ω-3 FA supplementation on in vivo GSH concentration in older adults at risk for depression. Fifty-one older adults at risk for depression were randomized to receive either four 1000-mg ω-3 FA supplements daily (containing eicosapentaenoic acid 1200 mg plus docosahexaenoic acid 800 mg) or placebo (four 1000-mg paraffin oil placebo capsules daily) for 12 wk. Participants underwent magnetic resonance spectroscopy, as well as medical, neuropsychological, and self-report assessments at baseline and after 12 wk of supplementation. GSH was measured in the thalamus and calculated as a ratio to creatine. Depressive symptoms were measured using the Patient Hea...Continue Reading

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Aug 30, 2016·Nutritional Neuroscience·Claire J ScavuzzoRyan J Larsen
Mar 31, 2017·European Archives of Psychiatry and Clinical Neuroscience·Daniel F HermensIan B Hickie
Sep 6, 2019·Nutrients·Deanna M Minich, Benjamin I Brown
Feb 16, 2020·European Journal of Clinical Pharmacology·Rakesh BalachandarBhavani Shankara Bagepally
Apr 17, 2019·Nutrients·Valentina CiappolinoPaolo Brambilla
Jan 29, 2019·Early Intervention in Psychiatry·Oliver D RobertsonSeetal Dodd
Jan 30, 2021·Alzheimer Disease and Associated Disorders·Ashlee TurnerShantel L Duffy

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