The effect of 17beta-estradiol in attenuating experimental subarachnoid hemorrhage-induced cerebral vasospasm

Journal of Neurosurgery
Chih-Lung LinChin Hsu

Abstract

Sex differences in the outcome of aneurysmal subarachnoid hemorrhage (SAH) are controversial, and the potential influence of estradiol on vasodilation is unclear. In the present study the authors evaluate the effect and possible mechanism of 17beta-estradiol (E2) on SAH-induced vasospasm in a two-hemorrhage rodent model of SAH. A 30-mm Silastic tube filled with E2 in corn oil (0.3 mg/ml) was subcutaneously implanted in male rats. Serum levels of E2 were measured on Days 0, 1, 2, 3, 4, and 7 postimplantation. The degree of vasospasm was determined by averaging the cross-sectional areas of the basilar artery (BA) 7 days after the first SAH. Expressions of endothelial nitric oxide synthase (eNOS) and inducible NOS (iNOS) in the BA were also evaluated. Serum levels of E2 in the E2-treated rats were at physiological levels (56-92 pg/ml) and were significantly higher than those in the control and vehicle-treated groups. Treatment with E2 significantly (p < 0.01) attenuated SAH-induced vasospasm. Induction of iNOS messenger (m)RNA and protein in the BA by SAH was significantly diminished by the E2 treatment but not by vehicle treatment. The SAH-induced suppression of eNOS mRNA and protein was relieved by E2 treatment. These results su...Continue Reading

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Citations

Dec 27, 2007·Neurologia Medico-chirurgica·Salih GulsenTuncalp Ozgen
Jul 6, 2006·Neurosurgical Focus·Scott Y RahimiCargill H Alleyne
Jun 27, 2014·BioMed Research International·Giulia CossuRoy Thomas Daniel
Dec 19, 2013·Current Treatment Options in Neurology·Saef Izzy, Susanne Muehlschlegel
Feb 18, 2014·Clinical Neurology and Neurosurgery·Nohra ChalouhiPascal Jabbour
Apr 29, 2018·Acta neurochirurgica·Marvin Darkwah OppongRamazan Jabbarli

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hormone replacement therapy

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