PMID: 1299438Jan 1, 1992

The effect of 2- and 3-component hyperbaric breathing mixtures on the self-stimulation reaction and on the skeletal muscle electromyogram of rabbits

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine
A Iu Sledikov


The effects of two- and three-component normoxic mixtures on self-stimulation and total bioelectrical activity of the skeletal muscles were evaluated in six test runs with 37 male rabbits. The increased partial pressures of He and N2 are found to affect differently intensity of self-stimulation which is enhanced in an O2-N2 environment and suppressed in that one consisting of He-O2. The He-N2-O2 mixture in which N2 amounts to 6% under pressure of 40 kgs/cm2 does not cause significant changes in self-stimulation as compared to that exposed by He-O2 breathing mixture. In contrast, trimix breathing (N2 amounts to 6%) under the same pressure did not result in an elevation in amplitude of muscular electric activity observed when used hyperbaric He-O2 breathing mixture. The experimental results may be indicative of an involvement of different mechanisms in genesis of the nervous syndrome of high pressure as well as of the fact that adding of N2 to He-O2 mixture does not allow this pathologic state to be completely prevented.

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