PMID: 6562000Apr 1, 1984Paper

The effect of 2-mercaptoacetyl-L-phenylalanyl-L-leucine, a specific inhibitor of Pseudomonas aeruginosa elastase, on experimental Pseudomonas keratitis in rabbit eyes

Current Eye Research
A Spierer, E Kessler

Abstract

The compound 2-mercaptoacetyl-L-phenylalanyl-L-leucine (HS-Ac-Phe-Leu) is a potent and specific inhibitor of Pseudomonas aeruginosa elastase, effectively inhibiting the elastase activity both, in vitro and within the rabbit cornea. This inhibitor was therefore evaluated as an adjunct to antibiotics (gentamicin) treatment in experimentally induced Pseudomonas keratitis in rabbits. Twenty eight hours after infection, the eyes that received both, gentamicin and HS-Ac-Phe-Leu showed significantly less corneal melting than those treated with the antibiotics alone, demonstrating the beneficial effect of the inhibitor. Forty eight hours after infection, the difference in clinical appearance between the two treatment groups diminished and was statistically insignificant. No adverse effects were noted in the eyes that received the inhibitor in spite of its frequent application. The protective effect of HS-Ac-Phe-Leu, seen on the first day of the experiment suggests further exploration of the therapeutic potential of this or other, similarly structured, specific and potent inhibitors of Pseudomonas elastase.

References

Jul 1, 1977·International Journal of Dermatology·J E Rasmussen
Sep 1, 1970·The British Journal of Ophthalmology·L A Wilson
Nov 1, 1972·Archives of Ophthalmology·P R Laibson
Jan 1, 1974·Archives of Ophthalmology·G BohigianB L Caraway
Oct 17, 1983·European Journal of Biochemistry·S Blumberg, Z Tauber
Oct 1, 1980·The Journal of Infectious Diseases·D E OhmanB H Iglewski
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Citations

Nov 1, 1990·Antimicrobial Agents and Chemotherapy·F R BurnsJ T Wells
Dec 4, 2004·Biological Chemistry·Koki Matsumoto
Mar 1, 1990·Equine Veterinary Journal·D V HackerH Scagliotti
Apr 1, 1991·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·M McIntyreB P Berdal

Related Concepts

2-mercaptoacetyl-phenylalanylleucine
Dipeptides
Polychemotherapy
Gentacycol
Keratitis
Elastase I
Pseudomonas Infections

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