The effect of 4 weeks treatment with desloratadine (5mg daily) on levels of interleukin (IL)-4, IL-10, IL-18 and TGF beta in patients suffering from seasonal allergic rhinitis

Pulmonary Pharmacology & Therapeutics
Damian TworekP Kuna

Abstract

Anti-inflammatory effect of desloratadine (DL), including, but not limited to depression of production of IL-4, IL-6 and IL-8, has been shown in several in vitro experiments but only a few in vivo studies refer to this findings. The purpose of our study was to evaluate the influence of DL on levels of IL-4, IL-10, IL-18 and TGF-beta in sera of patients with seasonal allergic rhinitis (SAR). Sixty-nine subjects suffering from SAR with hypersensitivity to grass pollen were included into the evaluation of clinical efficacy of DL (5mg once daily). None of them was taking any H(1) receptor antagonist during the pollen season before inclusion into the study. Samples of peripheral blood were taken before and after 4 weeks of treatment. Levels of cytokines were determined using the ELISA method. The mean level of IL-4 was 0.212+/-0.07pg/ml before and 0.221+/-0.1pg/ml after the treatment (p=0.52); IL-10 5.13+/-3.14 and 4.71+/-0.88 (p=0.69); IL-18 54.45+/-26.09 and 44.80+/-22.42 (p=0.48); TGF beta 949.17+/-401.5 and 955.7+/-391.2 (p=0.97)pg/ml before and after the treatment, respectively. Unless in vitro DL demonstrates not only anti-allergic but also anti-inflammatory activities data from this in vivo study in a group of patients suffer...Continue Reading

References

Jan 1, 1988·Clinical Allergy·A Linder
Jan 1, 1994·Annual Review of Immunology·R A Seder, W E Paul
Jan 12, 2000·The Journal of Allergy and Clinical Immunology·T KodamaH Okamura
Oct 10, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J T SchroederW Kreutner
Apr 4, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·I StelmachP Kuna
Apr 26, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R LeursM Taglialatela
Nov 28, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·William E BergerUNKNOWN Desloratadine Study Group
Feb 18, 2004·The Journal of Clinical Investigation·Jae Youn ChoDavid H Broide
Apr 22, 2004·The Journal of Allergy and Clinical Immunology·Cédric DeruazFrançois Spertini
Jun 16, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G CiprandiM A Tosca
Mar 8, 2005·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·J GlückB Mazur

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Citations

Jul 17, 2018·Oxidative Medicine and Cellular Longevity·Ioana Adriana MunteanDiana Deleanu

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