The effect of a benzodiazepine, flurazepam, on the response of in vitro skeletal muscle preparations to muscle relaxants: are purines or their receptors involved?

Canadian Journal of Physiology and Pharmacology
J T Hamilton, P A Stone

Abstract

Changing trends in the use of anxiolytic agents and recent reassessment of their neuropharmacological activity has prompted this evaluation of the peripheral neuromuscular activity of the benzodiazepine, flurazepam. In previous reports we have documented peripheral neuromuscular activity of chlordiazepoxide and diazepam on the rat phrenic nerve diaphragm preparation. The water soluble benzodiazepine, flurazepam, has been studied on the rat phrenic nerve diaphragm and frog rectus abdominis in vitro. On the former preparation flurazepam enhanced and then blocked the response to indirect electrical stimulation (0.2 Hz) and readily blocked posttetanic potentiation and prevented the preparation from sustaining a tetanic contracture (30 Hz). On the later preparation, flurazepam blocked in a noncompetitive manner the response of the frog muscle to applied cholinergic agonists. Studies on the rat preparation with the neuromuscular blocking drug succinylcholine have shown an unexpected protection against blockade in preparations pretreated with low concentrations of flurazepam. This was not observed when flurazepam was given prior to d-tubocurarine. The application of adenosine to rat diaphragms during steady-state partial blockade caus...Continue Reading

Citations

Jul 2, 1987·European Journal of Pharmacology·R S LeeuwinH van Wilgenburg
Dec 12, 2001·Toxicon : Official Journal of the International Society on Toxinology·Steven D Aird
Jul 1, 1984·Medicinal Research Reviews·M Simonyi
Sep 23, 1997·Biochemical and Biophysical Research Communications·S RufiniW Malorni

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