PMID: 7522763Jan 1, 1994Paper

The effect of a blockade of the dopamine D2 receptors in the cat neostriatum on the neuronal background activity and reactions of the reticular portion of the substantia nigra related to saccadic eye movements

Fiziologicheskiĭ zhurnal imeni I.M. Sechenova
M Ia VoloshinB P Kolomiets

Abstract

In cats, the activity of the substantia nigra reticular part's neurons was extracellularly recorded prior to and after haloperidol administration into the head of the caudate nucleus. The number of neurons with burst-type firing increased after the administration from 34 to 61 per cent. The excitatory/inhibitory responses ratio associated with saccadic eyes movements also increased from 0.04 to 0.4. The above changes seem to follow a disinhibition of the GABA-ergic neurons under the effect of blockade of the neostriatum D2 dopamine receptors.

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here