The effect of a cyclodextrin vehicle on the cardiovascular profile of propofol in rats

Anesthesia and Analgesia
S J BielenW B Gough

Abstract

We studied the aqueous solution of propofol dissolved in hydroxypropyl-beta-cyclodextrin (HP beta CD) 20% to determine whether the cardiovascular profile differed from that measured for propofol prepared in Intralipid 10% (Diprivan). Conscious male rats were given an intravenous bolus of propofol, 5.0 mg/kg, the minimum dose that induces a loss of righting. Immediately severe bradycardia occurred which was the result of a combination of sinus arrest and atrioventricular block; a significant decrease of blood pressure resulted. A bolus of HP beta CD produced no significant changes in heart rate rhythm. The severe bradycardia produced by propofol in HP beta CD was blocked by both atropine and bilateral cervical vagotomy. Therefore, the effects of propofol in HP beta CD are cholinergic and neurally mediated. These results are consistent with the hypothesis that propofol reduces sympathetic tone prior to reduction in vagal tone, and thereby produces a period of time during which vagal tone is dominant.

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Citations

May 1, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J W Sear
Jun 6, 2000·Advanced Drug Delivery Reviews·V J StellaV Zia
Sep 29, 2001·Anaesthesia·R D MacPherson
Jun 3, 2014·Anesthesiology Clinics·M Stephen MeltonTong J Gan
May 26, 2004·International Journal of Pharmaceutics·Adriana TrapaniGaetano Liso
Sep 25, 2010·Revista brasileira de anestesiologia·Roberto Takashi SudoGisele Zapata-Sudo
Jun 14, 2008·British Journal of Anaesthesia·F RavenelleD C Smith

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