PMID: 8581416Sep 1, 1995Paper

The effect of a depleting anti-CD4 monoclonal antibody on T cells and fetal pig islet xenograft survival in various strains of mice

Transplant Immunology
T E MandelMaria Koulmanda

Abstract

The effect of a cell-depleting anti-CD4 monoclonal antibody (mAb), GK1.5, was studied in a number of strains of inbred mice. Young adult female NOD/Lt, CBA and BALB/c mice were transplanted with organ cultured fetal pig pancreas and given 0.3 mg of the mAb (as ascites) on days -1, 0 and +1. The grafts were mostly rejected within 13 days in CBA mice but BALB/c and NOD recipients still had essentially intact grafts with the NOD mice showing evidence of early rejection. By 28 days posttransplantation the BALB/c recipients still had well-preserved grafts with minimal infiltration, but NOD and CBA mice had generally rejected their grafts totally. Peritransplant mAb treatment reduced CD4+ T cells in the spleen and they showed only incomplete recovery by 28 days. To further analyse the effect of anti-CD4 treatment, these strains as well as C57BL/6 mice were given a single dose (0.3 mg) of GK1.5 either as ascites or as affinity purified mAb. There was no obvious difference in effect between the ascites and the purified mAb within a strain but the various strains showed consistent differences in their blood, spleen and lymph node lymphocytes and in their response to the mAb. C57BL/6 mice differed from the other strains in having fewer T...Continue Reading

References

Sep 1, 1991·European Journal of Immunology·A G Baxter, T E Mandel
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Citations

Mar 17, 1999·Transplantation Proceedings·J Kovarik, T E Mandel
Nov 26, 2003·Immunology and Cell Biology·Yifan ZhanAndrew M Lew
Oct 3, 2000·Transplantation·S YiP J O'Connell
Nov 5, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Thomas HaudebourgBernard Vanhove
Nov 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Y ZhanA M Lew

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