PMID: 8952622Sep 1, 1996Paper

The effect of a fluoridated toothpaste on dentinal lesions in plaque-filled grooves: an intra-oral crossover study

Journal of Dental Research
M D LagerweijJ M ten Cate

Abstract

Recently, we introduced an intra-oral dentin demineralization model to evaluate the efficacy of a fluoridated toothpaste at plaque-retention sites with limited access to salivary components and fluoride. Usage of the fluoridated toothpaste reduced mineral loss from grooves in sound dentin by 15% compared with a non-fluoridated toothpaste (Lagerweij et al., 1997). In the current study, preformed dentinal lesions were subjected to similar toothpaste treatments. To improve the power of the model in discriminating between toothpaste groups, we changed the design from monadic to crossover to reduce the influence of variation between the participants. Two sets of specimens were placed in the partial prostheses of 29 participants who used a toothpaste containing either 1000 ppm fluoride or no fluoride during two consecutive six-week periods. Changes in mineral content were analyzed by transverse microradiography. The average mineral loss after the non-fluoride period was 1785 vol% x micron (SD 2399), and 1335 vol% x micron (SD 2039) after the fluoride period, a 25% inhibition in demineralization. Analysis of variance showed that the demineralization was significantly influenced not only by the type of treatment (p < 0.001 level), but ...Continue Reading

References

Apr 1, 1992·Journal of Dental Research·G K StookeyA J Dunipace
Feb 1, 1990·Journal of Dental Research·J A Brunelle, J P Carlos
Jan 1, 1995·Caries Research·A J van StrijpJ M ten Cate
Jun 1, 1994·Scandinavian Journal of Dental Research·G E DijkmanJ Arends
Dec 1, 1995·European Journal of Oral Sciences·J M ten CateJ J Damen
Nov 1, 1987·Journal of Dental Research·R StrangK W Stephen

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Citations

Jul 5, 2003·Journal of Microbiological Methods·C K Hope, M Wilson
Apr 8, 2014·Journal of Dentistry·Arzu Aykut-YetkinerAnnette Wiegand
Jul 31, 2002·Journal of Dental Research·E ZauraJ M ten Cate
Oct 12, 2010·Journal of Dental Research·G C ValeJ A Cury
Jul 5, 2001·Journal of Dental Research·E Zaura-AriteJ M ten Cate

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