The effect of a high-calorie diet on bone growth is mediated by the insulin receptor

Bone
Shufang WuFrancesco De Luca

Abstract

Obese children grow faster than their normal-weight peers. Insulin resistance and hyperinsulinemia have been associated with obesity-related growth acceleration. To determine whether obesity-associated hyperinsulinemia promotes bone growth by activating the insulin receptor in the growth plate, we generated TamCartIRflox/flox mice. The injection of 4 doses of tamoxifen in these mice (beginning at postnatal day 5th with 2 days interval between injections) resulted in the Insulin Receptor (IR) gene excision exclusively in the cartilage. TamCartIRflox/flox tamoxifen-treated mice (KO mice) and their IRflox/flox control littermates (C mice) at 3 weeks of age were exposed to a standard or hypercaloric (high-fat) diet for 4 weeks. At the end of study, C and KO mice fed with a high-fat diet exhibited greater weight gain than the respective strains fed with a standard diet. Body and tibial growth and growth plate height of C mice fed with high-fat diet were greater than those of standard-diet-fed C mice; however, no difference was observed between KO mice fed with standard or high-fat diet with respect to body and tibial growth and growth plate height. Circulating levels of insulin, IGF-1 and leptin were significantly higher in C and KO...Continue Reading

Citations

Apr 7, 2020·Journal of Pediatric Orthopedics·Manuel Montañez-AlvarezMarisa Ramírez-Ruiz
Sep 17, 2019·World Journal of Diabetes·Silvia Costantini, Caterina Conte
Jul 31, 2021·World Journal of Diabetes·Giacomina BrunettiMaria Felicia Faienza

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