PMID: 2499985Mar 1, 1989Paper

The effect of a lipid food component on enzymatic activity of rat liver endoplasmic reticulum upon the action of polychlorinated biphenyls

Voprosy pitaniia
N V LashnevaZ M Gadzhiyeva

Abstract

The authors have studied the character of changes in the content of cytochrome P450 and b5, in the oxidation rate of amidopyrine, dimethyl-aniline and aniline, in the NADPH- and ascorbate-dependent lipid peroxidation systems, as well as in glucose-6-phosphatase and acetylesterase activities in the liver microsomes of the rats on semisynthetic diets, including 50% (according to calorific value) of butter or sunflower oil, or receiving fat-free diet (0.5% of sunflower oil) in different terms (4 and 70 days) after a single intragastric administration of a mixture of polychlorinated diphenyls, chlorinated biphenyl (500 mg/kg). It is shown that the degree and character of the microsomal enzymes studied, as well as the changes in the liver structure under the action of chlorinated biphenyl depend, to a certain extent, on the quality and quantity of fat in the diet.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.