PMID: 18491Jul 1, 1977Paper

The effect of a new benzodiazepine on the polygraphically monitored sleep of normal volunteers

Journal of Clinical Pharmacology
F R FreemonJ C Lee


All-night sleep was polygraphically monitored from ten normal volunteers who took placebo and three dosage levels of a new benzodiazepine hypnotic, SCH 16134, in a double-blind, crossover design. All dosages of the drug decreased the time to fall asleep, and the two highest dosages also decreased interspersed wakefulness. REM sleep was suppressed, but slow-wave sleep was not affected in this experiment. The subjective quality of sleep was improved by the new hypnotic. One subject reported that he felt lethargic the day after the largest dose.


Oct 15, 1973·Psychopharmacologia·J M Monti, H Altier
Jan 1, 1974·Pharmacology·M W Johns, J P Masterton
Nov 1, 1957·Electroencephalography and Clinical Neurophysiology·W DEMENT, N KLEITMAN


Jul 1, 1979·Journal of Clinical Pharmacology·A KalesE O Bixler
Feb 8, 2007·Journal of Anesthesia·Tomoki NishiyamaMasanobu Manabe
Jan 1, 1978·Acta Psychiatrica Scandinavica. Supplementum·W Lehmann
Apr 1, 1980·Journal of Clinical Pharmacology·A KalesP K Schweitzer
Jan 1, 1979·The Journal of International Medical Research·T RothM Kaffeman
Jan 1, 1983·The Journal of International Medical Research·J Mendels, S Stern

Related Concepts

Double-Blind Method
Sleep, Slow-Wave
Sleep, REM
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