The effect of a new slow-release, long-acting somatostatin analogue, lanreotide, in acromegaly

Clinical Endocrinology
M al-MaskariP Kendall-Taylor

Abstract

Previous studies have shown that somatostatin analogues such as octreotide and lanreotide are effective in suppressing GH and IGF-I levels in acromegaly, but the mode of administration and the frequency of injections were inconvenient for the patients. We have evaluated the effects of a new slow-release (SR), long-acting formulation of lanreotide, a somatostatin analogue, on clinical, biochemical and safety responses in acromegaly. We studied the effects of SR-lanreotide 30 mg administered intramuscularly twice or three times monthly for 6 months. Ten patients were studied, in whom acromegaly was confirmed by clinical features,mean GH > 5 mU/l, and failure to suppress GH to < 2 mU/l after a 75-g oral glucose load. Subjective improvement in clinical symptoms of acromegaly was graded and recorded. Any adverse reactions were noted. Plasma GH levels were measured every 10 min for one hour from 08300930h; fasting IGF-I levels were determined at 0830h; GH, glucose and insulin responses to oral glucose loading were measured at 0,30,60,90 and 120 minutes from 0930 to 1130h. Baseline measurements were carried out and repeated at 3 and 6 months. Biliary ultrasonography was performed at baseline and 6 months. GH levels in the 10 patients ...Continue Reading

Citations

Dec 29, 2007·Reviews in Endocrine & Metabolic Disorders·John D Carmichael, Vivien S Bonert
Apr 20, 1999·Endocrinology and Metabolism Clinics of North America·C B Newman
Aug 14, 2003·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Pamela U Freda
Sep 1, 1999·Clinical Endocrinology·H E TurnerJ A Wass
Jan 7, 2006·Postgraduate Medical Journal·J Ayuk, M C Sheppard
Nov 13, 2004·Hormone Research·Ian M Holdaway
Jun 1, 2001·Journal of Endocrinological Investigation·R AttanasioR Cozzi
Aug 27, 2009·Biologics : Targets & Therapy·Ferdinand RoelfsemaJohannes A Romijn
Mar 16, 2001·Expert Opinion on Pharmacotherapy·J J Díez, P Iglesias
Jan 5, 2002·Expert Opinion on Investigational Drugs·C Parkinson, P J Trainer
Jan 30, 2008·Endocrinology and Metabolism Clinics of North America·Anat Ben-Shlomo, Shlomo Melmed
Jan 15, 2008·Molecular and Cellular Endocrinology·Anat Ben-Shlomo, Shlomo Melmed
Mar 19, 2003·Clinical Endocrinology·Tomás LucasUNKNOWN Spanish Multicentre Lanreotide Study Group on Acromegaly
Sep 27, 2003·Clinical Endocrinology·Roberto BaldelliGuido Tamburrano
Apr 15, 2003·Neurosurgery Clinics of North America·Mary Lee Vance
Jul 26, 2000·Baillière's Best Practice & Research. Clinical Endocrinology & Metabolism·P M Stewart, R A James
Apr 6, 2002·Hospital Medicine·Stafford Lightman
Mar 29, 2018·The Journal of Clinical Endocrinology and Metabolism·Alessia CozzolinoAndrea M Isidori
Jan 15, 2005·Treatments in Endocrinology·Alberto M PereiraJohannes A Romijn
Feb 12, 2009·The Journal of Clinical Endocrinology and Metabolism·Gherardo MazziottiAndrea Giustina
May 1, 2006·Expert Review of Endocrinology & Metabolism·Nienke R BiermaszJohannes A Romijn
Apr 2, 2004·Journal of Endocrinological Investigation·R BaldelliF F Casanueva
Aug 6, 1999·Journal of Endocrinological Investigation·M SulimanD R Cullen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.