The effect of a nitric oxide donor on Doppler flow velocity waveforms in the uterine artery during the first trimester of pregnancy

Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
A AmitJ Itskovitz-Eldor

Abstract

Our objectives were to study the effect of a nitric oxide donor on uterine blood flow velocity waveforms and maternal heart rate and blood pressure during the first trimester of pregnancy. Eleven women were examined at 8-12 weeks' gestation, prior to elective termination of pregnancy. Each woman was randomly given a sublingual tablet containing 5 mg of isosorbide dinitrate or placebo, on two consecutive days. Measurements of maternal blood pressure, heart rate and Doppler flow velocity waveforms of the ascending branch of the main uterine artery were obtained before, and every 2 min (for 20 min) after taking the drug or placebo. Following administration of isosorbide dinitrate, the mean arterial blood pressure fell from a control value of 82.5 +/- 5.6 mmHg to a nadir of 73 +/- 4.1 mmHg at 16 min (p < 0.0001). The mean maternal heart rate increased from a control value of 80.9 +/- 2.8 beats/min to a peak of 90.4 +/- 4.6 beats/min at 10 min (p < 0.001). The mean resistance index in the uterine artery fell from a control value of 0.80 +/- 0.02 to a nadir of 0.73 +/- 0.03 at 10 min (p < 0.0001). Analysis of covariance was employed to compensate for the effect of heart rate on the resistance index. The drug had a significant effect ...Continue Reading

Citations

Apr 9, 2002·Fertility and Sterility·Wolfgang E PaulusKarl Sterzik
Oct 31, 2012·Current Opinion in Obstetrics & Gynecology·Madhavi KalidindiJoseph Aquilina
Jun 21, 2013·Drug Development and Industrial Pharmacy·Srinivasan ShanmugamJong Soo Woo
Feb 1, 2008·European Journal of Pharmacology·António José Santos-SilvaIgnacio Verde
Apr 18, 2006·American Journal of Obstetrics and Gynecology·Laura DettiElizabeth E Puscheck
Jun 6, 2018·Drug Delivery·Heba M AboudAbdel-Razik H Abdel-Razik
Jan 4, 2019·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M Gonser
Apr 20, 2007·The Cochrane Database of Systematic Reviews·S Meher, L Duley
Aug 28, 2021·International Journal of Molecular Sciences·Xiangqun Hu, Lubo Zhang

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