PMID: 9163639May 1, 1997Paper

The effect of a novel orally active selective PDE4 isoenzyme inhibitor (CDP840) on allergen-induced responses in asthmatic subjects

The European Respiratory Journal
P L HarbinsonT H Lee

Abstract

Recent studies have suggested that theophylline, a nonspecific phospho-diesterase inhibitor, has useful anti-inflammatory actions in asthma. Phosphodiesterase 4 (PDE4) represents the predominant PDE isoenzyme present in inflammatory cells. PDE4 inhibitors might, therefore, have beneficial effects in asthma. Side-effects, specifically nausea, have limited the use of existing agents. CDP840 is an orally active, potent and selective PDE4 inhibitor. We have examined the effect of CDP840 on the allergen-induced asthmatic response, its possible modes of action, and its tolerability at therapeutic doses. A total of 54 patients were recruited to three double-blind, placebo-controlled studies. The first study examined the effect of CDP840 (15 mg b.i.d. for 9.5 days) on the allergen-induced asthmatic response in patients with known dual response to allergen. A second study examined the effect of CDP840 (15 mg b.i.d. for 9.5 days) on airway responsiveness to histamine. A third study examined whether single dose CDP840 (15 and 30 mg) had significant bronchodilatory effects. In all studies, CDP840 was well-tolerated, with no patients reporting nausea. CDP840 did not lead to changes in baseline forced expiratory volume in one second (FEV1) a...Continue Reading

Citations

Jun 19, 1998·Cell Biochemistry and Biophysics·M J PerryR J Owens
Feb 28, 2004·Il Farmaco·Olga BrunoFranco Dallegri
May 5, 2000·Biochemical Pharmacology·D M Essayan
Dec 15, 2000·Neuropharmacology·A RobichaudC C Chan
May 29, 2002·Bioorganic & Medicinal Chemistry Letters·Daniel GuayYves Girard
May 29, 2002·Bioorganic & Medicinal Chemistry Letters·R P AlexanderG Higgs
Apr 3, 2003·Pulmonary Pharmacology & Therapeutics·Donna D GaleMark Chasin
Aug 26, 2000·Current Opinion in Chemical Biology·D W Hay
Sep 16, 1998·Current Opinion in Chemical Biology·M J Perry, G A Higgs
Feb 26, 2004·Paediatric Respiratory Reviews·Leslie HendelesSarah Chesrown
Oct 2, 2004·Nature Reviews. Drug Discovery·Peter J Barnes
Mar 31, 2000·Current Opinion in Pulmonary Medicine·M S Barnette, D C Underwood
Dec 12, 2002·Current Opinion in Pulmonary Medicine·Domenico Spina
Dec 1, 1999·Annals of the Rheumatic Diseases·L G Corral, G Kaplan
Sep 28, 2000·Canadian Journal of Physiology and Pharmacology·C SavoieA Robichaud
Feb 26, 1998·American Journal of Respiratory and Critical Care Medicine·T J Torphy
Oct 28, 2011·Respiratory Research·Gail M GauvreauPaul M O'Byrne
Mar 20, 2001·Pharmacotherapy·K V Blake
May 10, 2013·American Journal of Respiratory and Critical Care Medicine·Bianca BeghèLeonardo M Fabbri
Jun 1, 2000·Indian Journal of Pediatrics·J Legg, J Warner
Jul 5, 2005·Expert Opinion on Investigational Drugs·H J Dyke, J G Montana
Aug 7, 2007·Journal of Enzyme Inhibition and Medicinal Chemistry·Maria P GiovannoniVittorio Dal Piaz
Jul 5, 2005·Expert Opinion on Investigational Drugs·D A HandleyL Vaickus
Sep 18, 2012·Pulmonary Pharmacology & Therapeutics·Sana SiddiquiLyn M Moir
Nov 29, 2011·Survey of Ophthalmology·Khayyam DurraniC Stephen Foster
Jan 25, 2011·Pulmonary Pharmacology & Therapeutics·Zuzana Diamant, Domenico Spina
Apr 13, 2010·Pulmonary Pharmacology & Therapeutics·Nicola Smith, Kenneth J Broadley
Jul 29, 2008·British Journal of Pharmacology·D Spina
Jul 22, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B R LeakerT MacRury
Dec 21, 2006·International Immunopharmacology·Nicola Smith, Kenneth J Broadley
Aug 6, 2005·Pharmacology & Therapeutics·Michelle M Epstein
Jan 13, 2006·British Journal of Pharmacology·Victoria Boswell-SmithClive P Page
May 5, 2001·Expert Opinion on Pharmacotherapy·M E Krawiec, S E Wenzel
Apr 14, 2012·Current Opinion in Pharmacology·Clive P Page, Domenico Spina
Feb 7, 2001·Biochemical Pharmacology·W S Wong, D S Koh
Feb 24, 2001·Clinics in Chest Medicine·G T Ferguson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.