The effect of a paracetamol and morphine combination on dynorphin A levels in the rat brain

Biochemical Pharmacology
Maurizio SandriniS Candeletti

Abstract

The purpose of this study was to find out whether the combination of inactive doses of paracetamol (PARA) and morphine was able to change dynorphin (DYN) A levels, evaluated by radioimmunoassay, and whether naloxone or [(-)-2-(3 furylmethyl)-normetazocine] (MR 2266), a kappa-opioid antagonist, modifies or prevents the activity of this combination on nociception and on DYN levels. The work was suggested by our previous findings which demonstrated that inactive doses of PARA and morphine, when given in combination, share an antinociceptive effect, and that PARA, at antinociceptive doses, decreases DYN levels in the frontal cortex, thus indicating a selective action within the CNS. Our present results demonstrate that the combination of inactive doses of PARA (100 mg/kg) and morphine (3 mg/kg) is just as effective in decreasing the levels of DYN A as full antinociceptive doses of PARA or morphine alone in the frontal cortex of the rat. The values, expressed in pmol/g tissue, were: control = 2.83 +/- 0.20; paracetamol (100) = 2.60 +/- 0.23; morphine (3) = 2.73 +/- 0.24; paracetamol + morphine = 1.34 + 0.16 (P < 0.05). The decrease was partially antagonised by MR 2266, but not by naloxone, suggesting that the activity of PARA and mo...Continue Reading

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Citations

Jun 21, 2013·Journal of Neural Transmission·Pinar Elmas, Ahmet Ulugol
Dec 10, 2013·Environmental Toxicology and Pharmacology·Kamilla Blecharz-KlinEwa Widy-Tyszkiewicz
Feb 8, 2002·Journal of Clinical Pharmacology·Arnold R Gammaitoni, Matthew W Davis
Feb 1, 2005·European Journal of Pharmacology·Lisa GodfreyIan Kitchen
Jan 18, 2007·CNS Drug Reviews·Alfio BertoliniSheila Leone
Apr 3, 2012·Pharmacology, Biochemistry, and Behavior·Hugo F MirandaJuan Carlos Prieto
Jul 4, 2009·Acta Anaesthesiologica Scandinavica·A SalonenH Kokki
Jun 28, 2003·Natural Product Reports·Kenneth W Bentley
Jun 21, 2021·Early Human Development·Dimitrios AngelisLina Chalak

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