The effect of a propofol-based sedation technique on cumulative embryo scores, clinical pregnancy rates, and implantation rates in patients undergoing embryo transfers with donor oocytes

Journal of Clinical Anesthesia
M A RosenblattL Grunfeld

Abstract

To determine the effect, if any, of a propofol-based sedation technique on the reproductive outcomes of patients undergoing embryo transfers with donor oocytes. These ova recipients form a unique subgroup, whose clinical outcomes are unrelated to direct anesthetic effects on their reproductive tracts. Retrospective chart review. A 1200-bed university medical center. 117 patients who received fresh embryo transfer cycles between January 1991 and December 1995. The anesthesia records of 106 women who donated ova were reviewed for propofol usage during the transvaginal needle aspiration of the ova. The medical records of the 117 patients who received these donated embryos were reviewed for cumulative embryo scores, clinical pregnancy rates, and implantation rates. Fourteen patients received ova from women who were sedated with fentanyl and midazolam during ovum retrievals, while 103 patients received ova from women who had been given fentanyl, midazolam, and propofol in doses of 1.87 mg/kg to 8 mg/kg. The pregnancy rate among all patients who received ova from women who received propofol (44 of 103 = 42.7%) was 14.1% greater than those whose ovum donors did not receive propofol (4 of 14 = 28.6). 78.6% of both propofol and non prop...Continue Reading

Citations

Jan 24, 1998·Journal of Clinical Anesthesia·H A Hein, J M Putman
Dec 2, 2005·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Newton L Dias FilhoAndré H Rosa
Oct 31, 2015·Reproductive Biomedicine Online·Evangelia GoutziomitrouBasil C Tarlatzis
Jan 12, 2007·International Anesthesiology Clinics·Lawrence C Tsen
Jan 1, 1997·Critical Reviews in Biochemistry and Molecular Biology·P M Rudd, R A Dwek
Apr 25, 2003·International Anesthesiology Clinics·Patricia M Sequeira
Mar 11, 1999·Anesthesia and Analgesia·R MartinS Datta

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