PMID: 6966256Jan 1, 1980Paper

The effect of a protein-bound polysaccharide from Coriolus versicolor on immunological parameters and experimental infections in mice

Infection
P Mayer, J Drews

Abstract

The influence of PSK, a protein bound polysaccharide from Coriolus versicolor on various immunological parameters was studied, PSK was found to enhance B cell activity as measured by the spleen plaque-forming cell assay in mice, and to stimulate mouse macrophages as determined by an enhancement of carbon clearance and an increase in the phagocytosis of opsonized sheep red blood cells by peritoneal mouse macrophages in vitro. The activation of mouse macrophages by PSK appeared to correlate with the therapeutic effects of the compound. In mice made granulocytopenic with cyclophosphamide and subsequently infected with a variety of garm-negative pathogens or with Candida albicans, PSK prolonged the average survival time of the animals. The compound also led to a drastic increase in the number of animals surviving such experimental infections as compared to untreated controls. Possible mechanisms responsible for these protective effects by PSK are discussed.

References

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Citations

Mar 15, 1984·Klinische Wochenschrift·J Drews
Aug 1, 1983·European Journal of Clinical Microbiology·C T Keane, M T Cafferkey
Dec 1, 1982·European Journal of Clinical Microbiology·P K Peterson
Jan 1, 1989·Transactions of the Royal Society of Tropical Medicine and Hygiene·T SchettersW Eling
Jun 1, 1986·Veterinary Immunology and Immunopathology·T Kitao, Y Yoshida
Nov 26, 1998·Chemosphere·M L YuY L Guo
Jan 21, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·J E EylesH O Alpar
Sep 23, 2003·Biotechnology Advances·Jian Cui, Yusuf Chisti
Oct 21, 1999·International Journal of Antimicrobial Agents·K Christiansen
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·H SakellarisJ R Scott
Jan 1, 1988·JPEN. Journal of Parenteral and Enteral Nutrition·W C FanslowF B Rudolph
Nov 1, 1994·The Journal of International Medical Research·C K WongY M Choy

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