PMID: 9441013Jan 24, 1998Paper

The effect of a short-term reducing diet on the effect of insulin in type 2 diabetes mellitus

Casopís lékar̆ů c̆eských
G SindelkaV Justová

Abstract

Insulin resistance is in addition to impaired beta-cell function decisive for the development of type 2 diabetes. It is also known that obesity creates conditions for the development of insulin resistance. The authors tried therefore to influence insulin sensitivity by short-term reducing diets in obese type 2 diabetics. The group of patients comprised 12 obese type 2 diabetics, BMI: 40.3 +/- 8.9 kg/m2, age 50 +/- 8 years. The control group was formed by 12 healthy non-obese subjects. The following parameters of glucose tolerance were assessed: total glucose consumption to maintain euglycaemia (M) during an isoglycaemic hyperinsulinaemic clamp on a Biostator, index of tissue sensitivity to insulin (M/I), metabolic glucose clearance (MCRG), number of insulin receptors on erythrocytes (Ro) and the insulin affinity for receptors (Ko). A reducing diet, 600 kcal/day, was served for 7 days during hospitalization. The body weight of diabetics dropped by 3.2 +/- 1.5 kg, p < 0.001, there was a significant decline of the basal blood sugar level (G(o)) from 11.4 +/- 3.6 to 8.4 +/- 3.0 mmol/l, p < 0.01; 2 there was a significant reduction of the serum insulin level (Io) from 30 +/- 18 to 27 +/- 19 mU/l, p < 0.02, whereby glucose uptake M i...Continue Reading

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