PMID: 6629592Jan 1, 1983Paper

The effect of a single dose of cyclophosphamide on the kinetics of antibody production in the guinea pig

International Journal of Immunopharmacology
K DrösslerJ L Turk

Abstract

Cyclophosphamide (CY) 250 mg/kg was given before, at the same time or after immunization with dinitrophenylated bovine gammaglobulin (DNP47-BGG) in Freund's incomplete adjuvant (FIA). CY, given on day +3 or +7 strongly suppressed both IgG subclasses. CY, on the day of immunization, reduced the IgG2 but not IgG1 anti-DNP antibody synthesis. Carrier BGG, injected 42 days after initial immunization, caused a secondary anti-hapten IgG1 response. This was not altered by CY treatment. The secondary anti-BGG response in animals pretreated with CY was also not affected. However, IgG1 anti-BGG in the other groups given CY on day 0, +3 or +7 was delayed and reduced. IgG2 anti-BGG was suppressed in guinea-pigs treated with CY, 3 or 7 days after primary immunization. DNP-BGG-specific IgE serum antibodies, not detectable in CY untreated animals, were found in guinea pigs given CY on days 0, +3 or +7. It is suggested that the kinetics of the IgG1 and IgG2 primary immune response differ, as does the development of IgG1 and IgG2 specific immunological memory.

References

Jan 1, 1976·International Archives of Allergy and Applied Immunology·Z OvaryS Kojima
Nov 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·M B Rittenberg, K L Pratt

Citations

Dec 1, 2002·Nutrition Research Reviews·Alan W Bell, Richard A Ehrhardt
Aug 14, 2019·Waste Management & Research : the Journal of the International Solid Wastes and Public Cleansing Association, ISWA·Ghulam AliFaheem Shah

Related Concepts

Antibody Formation
BCG Vaccine
Cyclophosphamide, (S)-Isomer
Dinitrobenzenes
Dose-Response Relationship, Drug
Cavia porcellus
Immunoglobulin E
Polyglobin
Immunologic Memory

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