The effect of a single early high-dose vitamin D supplement on fracture union in patients with hypovitaminosis D: a prospective randomised trial

The Bone & Joint Journal
N HainesM A Karunakar

Abstract

To evaluate the effect of a single early high-dose vitamin D supplement on fracture union in patients with hypovitaminosis D and a long bone fracture. Between July 2011 and August 2013, 113 adults with a long bone fracture were enrolled in a prospective randomised double-blind placebo-controlled trial. Their serum vitamin D levels were measured and a total of 100 patients were found to be vitamin D deficient (< 20 ng/ml) or insufficient (< 30 ng/mL). These were then randomised to receive a single dose of vitamin D3 orally (100 000 IU) within two weeks of injury (treatment group, n = 50) or a placebo (control group, n = 50). We recorded patient demographics, fracture location and treatment, vitamin D level, time to fracture union and complications, including vitamin D toxicity. Outcomes included union, nonunion or complication requiring an early, unplanned secondary procedure. Patients without an outcome at 15 months and no scheduled follow-up were considered lost to follow-up. The t-test and cross tabulations verified the adequacy of randomisation. An intention-to-treat analysis was carried out. In all, 100 (89%) patients had hypovitaminosis D. Both treatment and control groups had similar demographics and injury characteristic...Continue Reading

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Citations

Oct 30, 2019·Archives of Orthopaedic and Trauma Surgery·Willem-Jan MetsemakersUNKNOWN Fracture-Related Infection (FRI) group
May 15, 2019·Journal of Orthopaedic Trauma·Patrick F BerginMichael T Archdeacon
Feb 20, 2020·EFORT Open Reviews·Hagen SchmalUNKNOWN Danish Orthopaedic Trauma Society
Oct 3, 2020·JBJS Reviews·Michael J DeRogatisKenneth A Egol
Mar 25, 2021·Nutrition·Lidwien MoonenInger Schipper
Sep 21, 2020·The Orthopedic Clinics of North America·David J Ruta, David Parker
May 21, 2021·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T ChevalleyR Rizzoli
Aug 14, 2021·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Antonios A KoutalosTheofilos Karachalios
Sep 8, 2021·Bone & Joint Open·Alexander ZargaranAlex J Trompeter

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