The effect of a slow mode of BMP-2 delivery on the inflammatory response provoked by bone-defect-filling polymeric scaffolds

Biomaterials
Gang WuErnst B Hunziker

Abstract

We investigated the inflammatory response to, and the osteoinductive efficacies of, four polymers (collagen, Ethisorb, PLGA and Polyactive) that bore either an adsorbed (fast-release kinetics) or a calcium-phosphate-coating-incorporated (slow-release kinetics) depot of BMP-2. Titanium-plate-supported discs of each polymer (n = 6 per group) were implanted at an ectopic (subcutaneous) ossification site in rats (n = 48). Five weeks later, they were retrieved for a histomorphometric analysis of the volumes of ectopic bone and foreign-body giant cells (a gauge of inflammatory reactivity), and the degree of polymer degradation. For each polymer, the osteoinductive efficacy of BMP-2 was higher when it was incorporated into a coating than when it was directly adsorbed onto the material. This mode of BMP-2 carriage was consistently associated with an attenuation of the inflammatory response. For coated materials, the volume density of foreign-body giant cells was inversely correlated with the volume density of bone (r(2) = 0.96), and the volume density of bone was directly proportional to the surface-area density of the polymer (r(2) = 0.97). Following coating degradation, other competitive factors, such as the biocompatibility and the ...Continue Reading

References

Dec 1, 1990·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·F R RozemaH W Jansen
Sep 1, 1987·Journal of Microscopy·H J Gundersen, E B Jensen
Jun 1, 1986·Journal of Microscopy·A J BaddeleyL M Cruz-Orive
Dec 1, 1995·Archives of Otolaryngology--head & Neck Surgery·T IizukaC Lindqvist
Nov 13, 1998·The Journal of Cell Biology·H SterlingA Vignery
Jun 24, 1999·Journal of Biomedical Materials Research·H UludagJ Wozney
Apr 5, 2001·Journal of Biomedical Materials Research·W G BrodbeckJ M Anderson
Aug 24, 2001·International Journal of Oral and Maxillofacial Surgery·R KontioC Lindqvist
Aug 28, 2001·Journal of Biomedical Materials Research·Y LiuK de Groot
Jan 5, 2002·Neurological Research·T A BarboltS H Liu
Jan 17, 2002·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·K U LewandrowskiW W Tomford
Jul 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·William G BrodbeckJames M Anderson
Jul 17, 2004·Annual Review of Biomedical Engineering·Buddy D Ratner, Stephanie J Bryant
Oct 13, 2004·Journal of Biomedical Materials Research. Part a·Limin Guan, John E Davies
Jun 14, 2005·Biomaterials·Annabel T TsaiCecilia M Giachelli
Jul 15, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·K PuumanenN Ashammakhi
Sep 5, 2006·The Journal of Bone and Joint Surgery. American Volume·D Luis MuscoloMaximiliano Ranalletta
Dec 26, 2006·Journal of Dental Research·Y LiuE B Hunziker
Mar 27, 2007·Injury·Joshua S Carson, Mathias P G Bostrom
Sep 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Hirokazu OhtakiDarwin J Prockop
Sep 25, 2008·The Journal of Craniofacial Surgery·Darren M SmithJoseph E Losee

❮ Previous
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Citations

Nov 17, 2011·Stem Cells and Development·Michelle A ScottAaron W James
Jun 11, 2014·International Journal of Molecular Sciences·Jianfeng WangGang Wu
May 17, 2014·International Journal of Molecular Sciences·Mirja FaßbenderBritt Wildemann
Dec 3, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Salwa SulimanKamal Mustafa
Oct 25, 2011·Biomaterials·Juthamas RatanavarapornYasuhiko Tabata
Jul 20, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Catrin StrobelBritt Wildemann
Feb 15, 2012·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Dan LiChangyou Gao
Apr 22, 2015·Tissue Engineering. Part a·Ernst B HunzikerNahoko Shintani
Mar 2, 2017·International Journal of Molecular Sciences·Hairong HuangGang Wu
Mar 8, 2016·International Journal of Molecular Sciences·Haiping LuGang Wu
Mar 24, 2018·Journal of Biomedical Materials Research. Part a·Yuelian LiuErnst B Hunziker
Apr 22, 2015·The Open Biomedical Engineering Journal·X LinY Liu
Nov 30, 2013·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·N M A I HanssenA D Verburg
Nov 19, 2011·Journal of Clinical Periodontology·Jingxiao WangGang Wu
Dec 30, 2014·Clinical Oral Implants Research·Tie LiuYuelian Liu
Mar 25, 2020·Maxillofacial Plastic and Reconstructive Surgery·Seong-Gon Kim
Jun 17, 2020·Tissue Engineering. Part a·Fan YangErnst B Hunziker

❮ Previous
Next ❯

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