The effect of a spot-on formulation containing polyunsaturated fatty acids and essential oils on dogs with atopic dermatitis

The Veterinary Journal
M BlaskovicR S Mueller

Abstract

Recent studies have shown that immunological aberrations and epidermal barrier defects could be important in the pathogenesis of canine atopic dermatitis (CAD) and that oral polyunsaturated fatty acids (PUFAs) might influence the epidermal barrier. The aim of this study was to evaluate the effects of a spot-on formulation containing PUFAs and essential oils on pruritus and lesions caused by CAD. Forty-eight privately owned dogs of different breeds, ages and genders diagnosed with atopic dermatitis were included in a randomized, double-blinded, placebo-controlled, multicentre clinical trial. Dogs were treated with a spot-on formulation containing PUFAs and essential oils or placebo on the dorsal neck once weekly for 8weeks. Before and after the study, CAD extent and severity index-03 (CADESI-03) and pruritus scores were determined by veterinarians and owners, respectively. There was significantly more improvement in CADESI-03 and pruritus scores in the treatment group than in the placebo group (P=0.011 and P=0.036, respectively). Additionally, more dogs improved by at least 50% in CADESI-03 and pruritus scores in the treatment group than in the placebo group (P=0.008 and P=0.070, respectively). No adverse reactions were observed...Continue Reading

References

Sep 1, 1992·Research in Veterinary Science·K L Campbell, G P Dorn
Jan 1, 1988·Progress in Lipid Research·V A Ziboh, R S Chapkin
Sep 13, 2001·Veterinary Immunology and Immunopathology·P B Hill, D J DeBoer
Sep 13, 2001·Veterinary Immunology and Immunopathology·C E Griffin, D J DeBoer
Sep 13, 2001·Veterinary Immunology and Immunopathology·T OlivryA Hillier
Jun 23, 2004·The Journal of Small Animal Practice·R S MuellerT L Greenwalt
Mar 25, 2005·Journal of Animal Physiology and Animal Nutrition·C AbbaG Raviri
Mar 16, 2007·Veterinary Dermatology·Thierry OlivryUNKNOWN International Task Force On Canine Atopic Dermatitis
Sep 12, 2007·Veterinary Dermatology·P B HillJ Rybnicek
Mar 14, 2008·Veterinary Dermatology·Annemarie E Merryman-SimpsonTim Nuttall
May 15, 2008·Veterinary Dermatology·Thierry OlivryUNKNOWN International Task Force on Canine Atopic Dermatitis
Apr 24, 2009·Journal of Cell Science·Aileen SandilandsW H Irwin McLean
Apr 28, 2009·Journal of Dermatological Science·Shona H WoodStuart D Carter
Mar 2, 2010·Veterinary Dermatology·Thierry OlivryHywel C Williams
Jun 16, 2011·Journal of the American Animal Hospital Association·Sandra Tretter, Ralf S Mueller

❮ Previous
Next ❯

Citations

Nov 21, 2015·The Veterinary Journal·Manolis N Saridomichelakis, Thierry Olivry
Aug 16, 2015·BMC Veterinary Research·Thierry OlivryUNKNOWN International Committee on Allergic Diseases of Animals
May 9, 2019·Journal of the American Veterinary Medical Association·Timothy J NuttallValerie A Fadok
Apr 9, 2020·Veterinary Sciences·Andrea MarchegianiMatteo Cerquetella
Nov 7, 2019·The Veterinary Record·Nicola MartinezFernando Martínez-Taboada
Dec 26, 2018·Natural Product Research·Anil Kumar MauryaDnyaneshwar Umrao Bawankule
Mar 22, 2020·BMC Veterinary Research·Rosanna MarsellaLluís Ferrer
Mar 6, 2021·The Veterinary Record·Manolis N SaridomichelakisRalf S Mueller

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.