Abstract
Recent studies have shown that immunological aberrations and epidermal barrier defects could be important in the pathogenesis of canine atopic dermatitis (CAD) and that oral polyunsaturated fatty acids (PUFAs) might influence the epidermal barrier. The aim of this study was to evaluate the effects of a spot-on formulation containing PUFAs and essential oils on pruritus and lesions caused by CAD. Forty-eight privately owned dogs of different breeds, ages and genders diagnosed with atopic dermatitis were included in a randomized, double-blinded, placebo-controlled, multicentre clinical trial. Dogs were treated with a spot-on formulation containing PUFAs and essential oils or placebo on the dorsal neck once weekly for 8weeks. Before and after the study, CAD extent and severity index-03 (CADESI-03) and pruritus scores were determined by veterinarians and owners, respectively. There was significantly more improvement in CADESI-03 and pruritus scores in the treatment group than in the placebo group (P=0.011 and P=0.036, respectively). Additionally, more dogs improved by at least 50% in CADESI-03 and pruritus scores in the treatment group than in the placebo group (P=0.008 and P=0.070, respectively). No adverse reactions were observed...Continue Reading
References
Sep 1, 1992·Research in Veterinary Science·K L Campbell, G P Dorn
Jan 1, 1988·Progress in Lipid Research·V A Ziboh, R S Chapkin
Jan 8, 1994·The Veterinary Record·R Bond, D H Lloyd
Sep 18, 1999·Veterinary Immunology and Immunopathology·M N SaridomichelakisL Leontidis
Jan 5, 2000·The American Journal of Clinical Nutrition·V A ZibohY Cho
Sep 13, 2001·Veterinary Immunology and Immunopathology·P B Hill, D J DeBoer
Sep 13, 2001·Veterinary Immunology and Immunopathology·T Olivry, P B Hill
Sep 13, 2001·Veterinary Immunology and Immunopathology·C E Griffin, D J DeBoer
Sep 13, 2001·Veterinary Immunology and Immunopathology·T OlivryA Hillier
Jun 23, 2004·The Journal of Small Animal Practice·R S MuellerT L Greenwalt
Jun 25, 2004·Veterinary Dermatology·Bente K SaevikFlemming Kristensen
Mar 25, 2005·Journal of Animal Physiology and Animal Nutrition·C AbbaG Raviri
Jan 18, 2006·Veterinary Dermatology·Jean SteffanRalf Mueller
Sep 12, 2006·Veterinary Dermatology·R MarsellaJ Lopez
Mar 16, 2007·Veterinary Dermatology·Thierry OlivryUNKNOWN International Task Force On Canine Atopic Dermatitis
Sep 12, 2007·Veterinary Dermatology·P B HillJ Rybnicek
Mar 14, 2008·Veterinary Dermatology·Annemarie E Merryman-SimpsonTim Nuttall
Apr 1, 2008·Journal of Comparative Pathology·A PiekutowskaM Haftek
May 15, 2008·Veterinary Dermatology·Thierry OlivryUNKNOWN International Task Force on Canine Atopic Dermatitis
Apr 24, 2009·Journal of Cell Science·Aileen SandilandsW H Irwin McLean
Apr 28, 2009·Journal of Dermatological Science·Shona H WoodStuart D Carter
Mar 2, 2010·Veterinary Dermatology·Thierry OlivryHywel C Williams
Mar 2, 2010·Veterinary Dermatology·Claude FavrotFedericca Picco
Mar 2, 2010·Veterinary Dermatology·Melanie E StehleRalf S Mueller
Jun 16, 2011·Journal of the American Animal Hospital Association·Sandra Tretter, Ralf S Mueller
Mar 1, 2012·Clinical and Experimental Dermatology·I PopaJ Portoukalian
Citations
Mar 19, 2016·Food Chemistry·Sergio BenavidesWendy Franco
Nov 21, 2015·The Veterinary Journal·Manolis N Saridomichelakis, Thierry Olivry
Aug 16, 2015·BMC Veterinary Research·Thierry OlivryUNKNOWN International Committee on Allergic Diseases of Animals
Jun 10, 2014·Veterinary Dermatology·Ashley N StichCraig E Griffin
Feb 22, 2017·Veterinary Dermatology·Stefan HobiRalf S Mueller
Sep 27, 2018·Veterinary Dermatology·Courtney Meason-SmithAline Rodrigues Hoffmann
Feb 8, 2019·Veterinary Dermatology·Rebecca Huhmann, Ralf S Mueller
May 9, 2019·Journal of the American Veterinary Medical Association·Timothy J NuttallValerie A Fadok
Apr 9, 2020·Veterinary Sciences·Andrea MarchegianiMatteo Cerquetella
Feb 7, 2020·Veterinary World·Nathaly EncisoJavier Enciso
Nov 7, 2019·The Veterinary Record·Nicola MartinezFernando Martínez-Taboada
Jun 25, 2020·Antibiotics·Gabriele MeroniPiera Anna Martino
Dec 26, 2018·Natural Product Research·Anil Kumar MauryaDnyaneshwar Umrao Bawankule
Mar 22, 2020·BMC Veterinary Research·Rosanna MarsellaLluís Ferrer
Nov 3, 2020·Veterinary World·Galia Sheinberg WaisburdLinda G Bautista Gómez
Mar 6, 2021·The Veterinary Record·Manolis N SaridomichelakisRalf S Mueller
Dec 21, 2016·Journal of Agricultural and Food Chemistry·Sanjeewa R KarunathilakaCynthia T Srigley
Nov 28, 2019·Complementary Medicine Research·Doris BismarckElisabeth Müller