PMID: 40568Jan 1, 1978

The effect of a sub-chronic administration of three dose levels of a 1,5-benzodiazepine derivative, clobazam, on subjective assessments of sleep and aspects of psychomotor performance the morning following night time medication

Arzneimittel-Forschung
I Hindmarch, A C Parrott

Abstract

The effect of repeated doses of a 1,5-benzodiazepine derivative, clobazam, at doses of 20, 30, and 40 mg taken at night was assessed the morning following medication on a variety of subjective and objective measures of sleep and psychomotor performance. None of the three dose levels of the drug produced any significant changes in critical flicher fusion thresholds or in complex reaction time tasks. Conceptual learning ability was not impaired by any of the doses of clobazam administered. Clobazam was rated on a self-scoring analogue rating scale as an effective sleep inducer, which also improved the perceived quality of sleep. There was also a reduction in the perceived integrity of early morning behaviour commensurate with the reported ease of getting to sleep.

Related Concepts

Motor Skills
Reaction Time
Sleep, Slow-Wave
Anti-Anxiety Effect
Analog
Benzodiazepine [EPC]
Concept Formation
Flicker Fusion
Night Time brand of acetaminophen, dextromethorphan, doxylamine, and pseudoephedrine
Benzodiazepines Assay

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.