The effect of a thromboxane A2 receptor antagonist BAY-u-3405 on experimental allergic reactions

Prostaglandins
H NagaiN Inagaki

Abstract

The effect of a novel thromboxane A2 receptor antagonist, BAY-u-3405, on experimental allergic airway and skin reactions was studied in vivo. At doses of 3-30 mg/kg BAY-u-3405 clearly inhibited the U-46619-induced increase in respiratory resistance (Rrs) in guinea pigs. BAY-u-3405 at doses of 3 and 30 mg/kg inhibited the aerosolized antigen-induced biphasic increase in respiratory resistance in guinea pigs. Moreover, BAY-u-3405 inhibited repeated aeroantigen-induced airway hyperactivity and airway inflammation in mice. In IgE antibody-mediated biphasic skin reactions in mice, both immediate and late-phase reactions were inhibited by 10 mg/kg of BAY-u-3405. These results demonstrate the efficacy of BAY-u-3405 on the antigen-induced late-phase reactions in the airway and skin in guinea pigs and mice, and antigen-induced airway hyperactivity in mice.

References

Nov 1, 1977·Clinical Allergy·D W CockcroftF E Hargreave
May 1, 1977·Clinical Allergy·D W CockcroftF E Hargreave
Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M HambergB Samuelsson
Nov 1, 1991·British Journal of Pharmacology·M G McKenniffP J Gardiner
Jan 1, 1985·International Archives of Allergy and Applied Immunology·S T HolgateM K Church
Feb 1, 1989·The Journal of Allergy and Clinical Immunology·F E Hargreave
Sep 1, 1987·The American Review of Respiratory Disease·P M O'ByrneF E Hargreave
Jan 1, 1988·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·I IwamotoS Yoshida
Feb 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·M HambergB Samuelsson
Jun 1, 1973·The Journal of Allergy and Clinical Immunology·V PopaA Bouhuys
Dec 1, 1984·The Journal of Allergy and Clinical Immunology·N YamauchiT Miyamoto
May 1, 1984·The Journal of Allergy and Clinical Immunology·J A Nadel
Jan 1, 1980·Medizinische Monatsschrift für Pharmazeuten·S Domschke, W Domschke
Aug 3, 1993·European Journal of Pharmacology·K ItohY Iizuka

❮ Previous
Next ❯

Citations

Jul 25, 2003·Biochemical and Biophysical Research Communications·Hiroyuki HiraiKinya Nagata
Mar 31, 2007·Nature Reviews. Drug Discovery·Roy PettipherRichard Armer
Dec 26, 2003·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Hiroyuki Hirai
Sep 20, 2011·Pharmacology & Therapeutics·Hiroichi Nagai
Jul 25, 2009·British Journal of Pharmacology·R L JonesD F Woodward
Mar 27, 2004·Biochemical and Biophysical Research Communications·Kazuya TanakaKinya Nagata
Mar 26, 2011·The Korean Journal of Internal Medicine·Masafumi Arima, Takeshi Fukuda
Mar 10, 2004·The Journal of Pharmacy and Pharmacology·Koichi NagaoHiroichi Nagai
Nov 6, 2004·The Journal of Pharmacology and Experimental Therapeutics·Yoshiki ShiraishiAkitoshi Ishizaka
Mar 22, 2003·The Journal of Pharmacology and Experimental Therapeutics·Hiromi SugimotoKevin B Bacon
Dec 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M MitsuhashiH Matsuda
Sep 17, 2004·Pharmacology & Therapeutics·Aaron N Hata, Richard M Breyer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.