PMID: 3746690May 1, 1986Paper

The effect of a transient outward current (IA) on synaptic potentials in sympathetic ganglion cells of the guinea-pig

The Journal of Physiology
J F Cassell, E M McLachlan

Abstract

The responses to stimulation of preganglionic fibres have been studied in sympathetic neurones in ganglia of the caudal lumbar sympathetic chain (l.s.c.) and in the distal lobes of inferior mesenteric ganglia (i.m.g.) isolated from guinea-pigs. Most l.s.c. neurones were classified as 'phasic' and i.m.g. neurones as 'tonic' (see Cassell, Clark & McLachlan, 1986). The types of preganglionic inputs received by l.s.c. and i.m.g. neurones differed: l.s.c. cells almost invariably received at least one suprathreshold ('strong') input, in addition to several subthreshold ones; i.m.g. neurones more commonly received only subthreshold inputs via the lumbar splanchnic nerves. Prolonged discharges were evoked in some i.m.g. cells by stimulation of lumbar splanchnic nerves at strengths just supramaximal for the conventional fast synaptic responses. These appeared to arise from repetitive discharges evoked in other neurones intrinsic to the i.m.g. The time constants of decay of subthreshold synaptic currents recorded under voltage clamp in l.s.c. neurones (4.9 +/- 0.2 ms) were significantly shorter on average than those recorded in tonic i.m.g. cells (7.1 +/- 0.3 ms), although the values of time constant for the two populations overlapped. I...Continue Reading

Citations

Jul 22, 1998·Journal of the Autonomic Nervous System·K Kukuła, P J Szulczyk
Dec 1, 1986·Journal of the Autonomic Nervous System·E M McLachlan, I J Llewellyn-Smith
Oct 1, 1992·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·J WiedehageE Buse
Sep 21, 2002·Autonomic Neuroscience : Basic & Clinical·Andrei Yu Bobryshev, Vladimir I Skok
Jan 10, 1998·The Journal of Physiology·S J BrookesM Costa
Dec 25, 2003·The Journal of Physiology·Ruth RuscheweyhJürgen Sandkühler
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May 13, 2003·Journal of Neurophysiology·John JamiesonElspeth M McLachlan
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