PMID: 18408776Apr 15, 2008Paper

The effect of accessibility to drugs on outcome of therapy in patients with malignant lymphoma

The Nigerian Postgraduate Medical Journal
C E Emoti, M E Enosolease

Abstract

To determine the compliance rate, reasons for default and factors affecting compliance. A prospective study of patients with malignant lymphoma (ML) at the University of Benin Teaching Hospital, Benin City, Nigeria. A total of 190 patients on chemotherapy for ML were followed up for between 6 and 18 months during study period (1995-2003). The reasons for default were recorded. Compliant and noncompliant patients were compared in terms of survival and sociodemographic data. Instat Package system for frequency counts, chi-squares and cross tabulations using Yates correction when necessary and the Fisher's exact test. Noncompliance rate was 63.2%. Major reasons for defaulting were high cost of drugs in 40 cases (33.3%), scarcity of drugs in 29 cases (24.2%) and side effects in 24 cases (20.6%). Compliance was significantly associated with higher levels of education, socioeconomic status, geographical abode (P<0.001) and gender (P= 0.031). Survival was found to be significantly associated with compliance in non-Hodgkin's lymphoma (NHL) (P>0.001) while the relative risk (RR) was below unity in ML. The level of compliance with medical therapy is still very poor. Health education and the provision of affordable, accessible and appropr...Continue Reading

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