The effect of acetyl-L-carnitine administration on persons with Down syndrome

Research in Developmental Disabilities
Siegfried M Pueschel

Abstract

Since previous investigations reported improvements in cognition of patients with dementia after acetyl-L-carnitine therapy and since there is an increased risk for persons with Down syndrome to develop Alzheimer disease, this study was designed to investigate the effect of acetyl-L-carnitine administration on neurological, intellectual, and social functions in adults with Down syndrome. In this double-blind study we enrolled 40 individuals with Down syndrome and administered acetyl-L-carnitine to the study group during a six months period. Specified examinations and psychological tests were given to persons in both the study and control groups at the start of the investigation and at 3, 6, and 9 months. A detailed analysis of the data revealed that acetyl-L-carnitine administration did not enhance central nervous system functions and that it did not benefit persons with Down syndrome.

Citations

Apr 20, 2010·Nutrition & Metabolism·Judith L FlanaganQian Garrett
Apr 22, 2009·Biogerontology·Najma Z BaquerDeepak Sharma
Oct 30, 2015·The Cochrane Database of Systematic Reviews·Nuala LivingstoneGeraldine Macdonald
Mar 30, 2017·The Cochrane Database of Systematic Reviews·Ning ChenLi He
Apr 28, 2020·American Journal of Medical Genetics. Part a·George CaponeUNKNOWN Down Syndrome Medical Interest Group (DSMIG-USA) Adult Health Workgroup
Jan 19, 2016·Current Opinion in Psychiatry·Na Young Ji, Robert L Findling
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