The effect of acetyl-L-carnitine on lenticular calpain activity in prevention of selenite-induced cataractogenesis

Experimental Eye Research
R ElanchezhianP A Thomas

Abstract

The present study sought to determine whether acetyl-L-carnitine (ALCAR) prevents selenite cataractogenesis by mechanisms involving lenticular calpain activity, Wistar rat pups were divided into 3 groups of 15 each. Group I (normal) rats received an intraperitoneal (i.p.) injection of normal saline on postpartum day 10; Group II (cataract-untreated) rats received a single subcutaneous (s.c.) injection of sodium selenite (19micromol/kg body weight) on postpartum day 10; Group III (cataract-treated) pups received a single s.c. injection of sodium selenite on postpartum day 10 and intraperitoneal injections of acetyl-L-carnitine (200mg/kg body weight) on postpartum days 9-14. At the end of the study period (postpartum day 16), both eyes of each rat pup were examined by slit-lamp biomicroscopy. There was dense lenticular opacification in all Group II rats, minimal lenticular opacification in 33% of Group III rats, and no lenticular opacification in 67% of Group III and in all Group I rats. Group II lenses exhibited significantly lower mean values of calpain activity and Lp82 (lens-specific calpain) protein expression, decreases in relative transcript level of m-calpain mRNA and significantly higher mean Ca(2+) concentrations than G...Continue Reading

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Citations

Jan 18, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·B N RoobanAnnie Abraham
Feb 23, 2010·Biological Trace Element Research·B N RoobanAnnie Abraham
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Aug 14, 2015·Journal of Chemical Information and Modeling·Arumugam Ramachandran MuralidharanPitchairaj Geraldine
Apr 18, 2020·Journal of Food Biochemistry·Nermin Abdel Hamid SadikHager Abd Al-Hamid

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