PMID: 9419088Jan 7, 1998Paper

The effect of acidic fibroblast growth factor and live yeast cell derivative on tympanic membrane regeneration in a rat model

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
S A GoldmanS P Cass

Abstract

The current treatment of choice for chronic tympanic membrane perforations is surgery. Recent studies using various polypeptide growth factors to accelerate closure of tympanic membrane perforations in model systems have produced mixed results. This study evaluates the effect of acidic fibroblast growth factor (AFGF) and live yeast cell derivative (LYCD) on the rate of healing of acute tympanic membrane perforations in a rat model. Thirty-seven rats had both ears separately randomized in a blinded fashion to receive AFGF in one of three concentrations, LYCD, or a control solution. The rats initially underwent subtotal removal of the tympanic membranes bilaterally. Solutions were applied to the randomized ears daily for 3 days, starting at the time of the surgical perforation. The ears were photographed every 3 to 8 days for 35 days. The photographs were digitally scanned and a computer analysis was used to calculate the percentage of residual perforation. No significant difference in the rate of healing was observed for ears treated with AFGF or LYCD versus the controls. Given the potential advantages of medical treatment of tympanic membrane perforations and the established efficacy of growth factors in other model systems, ho...Continue Reading

References

Jan 1, 1992·Growth Factors·T N MellinG Gimenez-Gallego
Oct 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·T D BjornssonK A Thomas
Oct 1, 1995·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·H A RamsayP K Laurila

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Citations

Oct 23, 2002·The Annals of Otology, Rhinology, and Laryngology·Shin-ichi Ishimoto, Toshio Ishibashi
Mar 3, 2001·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·R C O'ReillyS P Cass
Jul 19, 2018·The Journal of Laryngology and Otology·Z-C LouJ Xiao

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