The effect of ACTH stimulation on cortisol and progesterone concentrations in intact and ovariohysterectomized domestic cats

Theriogenology
Kaywalee ChatdarongCatharina Linde-Forsberg

Abstract

The objective was to evaluate the adrenocortical capacity for cortisol and progesterone production in female cats, both while intact and after ovariohysterectomy. Five privately owned female cats, 1-3 years old, were used in two trials while intact at an inactive stage of the cycle, and again in two trials, 2 weeks after ovariohysterectomy. The four trials were: intact saline injection control trial; intact ACTH injection (0.125 mg); ovariohysterectomized saline injection control trial; and ovariohysterectomized ACTH injection. Blood samples were obtained by an indwelling cephalic vein catheter at -30 and 0 min (immediately before injections) and at 60, 90, 120 and 180 min after injection. The mean basal pre-treatment concentrations of cortisol in the intact and ovariohysterectomized cats were 33 +/- 19 and 32 +/- 19 nmol/L, respectively; the corresponding values for progesterone were 1.1 +/- 0.6 and 0.7 +/- 0.6 nmol/L, respectively. Saline did not alter the serum cortisol or progesterone concentrations. In contrast, both cortisol and progesterone were elevated after ACTH, with peak values at 90 min and returned to basal levels at approximately 180 min. There was a positive correlation between cortisol and progesterone concentr...Continue Reading

References

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Citations

May 11, 2010·Theriogenology·Sandra Goericke-PeschAxel Wehrend
Jul 25, 2008·Reproduction in Domestic Animals = Zuchthygiene·E Axnér
Apr 5, 2013·Journal of Feline Medicine and Surgery·Mellora SharmanMatti Kiupel
Dec 1, 2007·Doklady Biological Sciences : Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections·S V NaidenkoM N Erofeeva
May 22, 2019·Journal of Veterinary Internal Medicine·Katarzyna A DembekRamiro E Toribio
Jun 18, 2021·Veterinary Medicine and Science·Naoaki YoshimuraTakeshige Otoi

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