PMID: 3129008Mar 1, 1988Paper

The effect of acute and chronic captopril therapy on baroreflex function in man

British Journal of Clinical Pharmacology
G B KondoweD W Harron


1. The effect of captopril 12.5 mg three times daily for 14 days on baroreflex sensitivity was investigated in six normotensive salt-replete male subjects. 2. Baroreflex sensitivity [delta R-R interval ms/mmHg systolic blood pressure (SBP)] was assessed following decreases and increases in SBP with glyceryl trinitrate and phenylephrine respectively and during Valsalva's manoeuvre. 3. Captopril had no effect on supine intra-arterial SBP or R-R interval on days 1 and 15 compared with placebo. However decreases (P less than 0.05) which occurred in plasma angiotensin II on day 1 (12.3 +/- 0.8 to 7.6 +/- 1.5 pg ml-1) and on day 15 (14.5 +/- 1.5 to 6.3 +/- 0.5 pg ml-1) and increases (P less than 0.02) in plasma renin activity on day 1 (1.2 +/- 0.7 to 4.8 +/- 0.8 ng A I ml-1 h-1) and on day 15 (1.1 +/- 0.2 to 5.4 +/- 0.9 ng A I ml-1 h-1) compared with placebo, indicated angiotensin-converting enzyme inhibition. 4. Baroreflex sensitivity was unchanged by captopril on day 1 and day 15 compared with placebo following the use of glyceryl trinitrate and phenylephrine to deactivate and activate respectively the baroreceptors, and during the strain and release phases of Valsalva's manoeuvre.


Sep 1, 1977·Circulation Research·G ManciaA Zanchetti
Nov 1, 1985·British Journal of Clinical Pharmacology·D W HarronR G Shanks
Jul 1, 1985·British Journal of Clinical Pharmacology·A A AjayiJ L Reid
Mar 1, 1986·British Journal of Clinical Pharmacology·A A Ajayi, J L Reid
Jan 1, 1985·European Journal of Clinical Pharmacology·R J FruncilloR K Ferguson
Jan 1, 1969·Circulation·J D BristowH S Smyth
Feb 1, 1982·British Journal of Clinical Pharmacology·B C CampbellJ L Reid
Nov 1, 1984·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J NussbergerE Haber
Apr 21, 1982·The American Journal of Cardiology·G ManciaA Zanchetti
Jan 1, 1982·British Journal of Pharmacology·E K Potter
Aug 1, 1982·Circulation·D S GoldsteinH R Keiser
Sep 1, 1963·Circulation Research·N P DEPASQUALE, G E BURCH


Sep 1, 1993·British Journal of Pharmacology·M P Rechtman, H Majewski
May 1, 1990·The Journal of Clinical Investigation·T R PorterP K Mohanty
Jul 24, 2004·Journal of Pharmacological Sciences·Yoshinobu TakataH Kato
Dec 1, 1996·Journal of Cardiovascular Pharmacology·T D GilesO Tresznewsky
May 8, 1999·The American Journal of Physiology·R BuñagB Allen

Related Concepts

Aldosterone, (11 beta,17 alpha)-Isomer
Angiotensin II, Val(5)-
Diastolic Blood Pressure
Double-Blind Method
Phenylephrine Hydrochloride
Reflex Action

Related Feeds

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.