PMID: 1982779Aug 1, 1990

The effect of acute and repeated hyperammonemia on gamma-glutamyl transpeptidase in homogenates and capillaries of various rat brain regions

Molecular and Chemical Neuropathology
W HilgierF Stastný

Abstract

The effect of hyperammonemia of varying degree and duration on the gamma-glutamyl-transpeptidase (GGT) activity was studied in the homogenates and capillaries of different brain regions of the rat. "Acute" hyperammonemia (750 and 600 mg of ammonium acetate per kg b.w. were injected i.p. at 30 min interval, and the animals were decapitated immediately), in which blood ammonia was increased 14-fold, and brain ammonia six-fold above the control level, produced a 20% increase of the enzyme activity in cerebellum, and a 17% decrease in gyrus dentatus, but had no effect in the frontal cortex and the CA1 and CA3 regions of hippocampus. "Subchronic" hyperammonemia (two injections of 600 mg ammonium acetate/kg were given at 24 h intervals, and tissue samples were removed 24 h later), that was accompanied by only a 60% increase of blood or brain ammonia, increased the activity in cerebellum to 38% above control, but produced no effect in the other brain regions. "Chronic" hyperammonemia (three injections of 600 mg ammonium acetate/kg at 24 h intervals and excision of tissue samples 30 min after the last injection), in which blood and brain ammonia were, respectively, 60 and 100% higher than in control animals, elevated the GGT activity i...Continue Reading

References

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Citations

Dec 1, 1993·Molecular and Chemical Neuropathology·Y Z ZiylanJ M Bourre
Aug 30, 2011·Neurotoxicity Research·Marta Skowrońska, J Albrecht
May 5, 2006·Fundamental & Clinical Pharmacology·M Mohamed Essa, P Subramanian
Feb 25, 2009·Molecular and Cellular Biochemistry·Selvaraju Subash, P Subramanian
Jan 1, 1994·Journal of Neurochemistry·W Hilgier, J E Olson

Related Concepts

Ammonia
Blood - Brain Barrier Anatomy
Blood Capillaries
Cerebellum
Insula of Reil
Cerebrovascular Circulation
Structure of Broca's Area
Gamma-glutamyl transferase
Structure of Subiculum Hippocampi
August Rats

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