The effect of acute coronary artery occlusion on subepicardial transmembrane potentials in the intact porcine heart

Circulation
E DownarD Durrer

Abstract

Subepicardial transmembrane potentials were recorded from intact pig hearts to observe the changes induced by acute ischemia. Ischemia shortened action potential duration, and decreased its amplitude, upstroke velocity, and resting potential. The cells were unresponsive after 12 to 15 minutes of coronary artery occlusion, yet near normal action potentials could be restored by flushing the occluded artery with saline as late as 40 minutes after occlusion. The unipolar extracellular electrogram reflected unresponsiveness by a monophasic potential. Local refractory periods initially shortened by up to 100 msec. Later, postrepolarization refractoriness occurred and refractory periods lengthened often in excess of basic cycle length, thus resulting in 2:1 responses. The onset of early ventricular arrhythmias often coincided with a period of alternation and 2:1 responses, especially when these got out of phase in different regions. Reperfusion frequently led to ventricular fibrillation, and was associated with marked inhomogeneity in cellular responses. Re-entry within ischemic myocardium was the most likely mechanism for arrhythmias.

References

Mar 1, 1977·The American Journal of Cardiology·S NaimiH J Levine
Sep 1, 1974·Circulation Research·R LazzaraB J Scherlag
Dec 1, 1970·The American Journal of Physiology·B J ScherlagA N Damato
Jun 1, 1960·The American Journal of Physiology·C M BROOKSH M MAZZELLA
Jan 1, 1964·Circulation Research·J HAN, G K MOE
Jul 1, 1960·Circulation Research·W E SAMSON, A M SCHER

❮ Previous
Next ❯

Citations

Oct 1, 1994·Pflügers Archiv : European journal of physiology·R Kumar, R W Joyner
Aug 1, 1986·Biulleten' eksperimental'noĭ biologii i meditsiny·E P AniukhovskiĭN V Shestakova
Sep 1, 1984·Basic Research in Cardiology·W J KriegerM J Janse
Oct 31, 2007·Medical & Biological Engineering & Computing·Mark PotseAlain Vinet
Jan 7, 1992·European Journal of Pharmacology·M McIntoshJ Parratt
Jan 1, 1985·Molecular Aspects of Medicine·J H BottingM J Walker
Jan 1, 1984·Pharmacology & Therapeutics·E Winslow
Aug 1, 1992·Journal of the American College of Cardiology·B Surawicz, C Fisch
Jan 13, 2004·Journal of Electrocardiology·José M Di Diego, Charles Antzelevitch
Jul 11, 2002·Journal of the American College of Cardiology·Antonis A ArmoundasHans D Esperer
Oct 1, 1990·Journal of the American College of Cardiology·M R FranzM M Scheinman
Feb 1, 1983·Journal of the American College of Cardiology·K R KarschW Schaper
Feb 1, 1983·Journal of the American College of Cardiology·G J AndersonC C Nydegger
Dec 1, 1983·Journal of the American College of Cardiology·J B MartinsD D Lund
Mar 1, 1985·Journal of the American College of Cardiology·D M Mirvis
Jun 1, 1985·Journal of the American College of Cardiology·B Surawicz
Aug 1, 1997·Journal of the American College of Cardiology·B SurawiczR P Pinto
Feb 1, 1997·Journal of Pharmacological and Toxicological Methods·T D BarrettM J Walker
Apr 12, 2003·Pacing and Clinical Electrophysiology : PACE·Stephane GarrigueJacques Clementy
Jul 14, 2010·Cardiovascular Research·David A Brown, Brian O'Rourke
Dec 6, 2007·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Brock M TiceNatalia Trayanova
Dec 16, 2000·Journal of Cardiovascular Pharmacology·G AmitzurM Eldar
Feb 28, 2002·Journal of Cardiovascular Pharmacology·Jacques M T de Bakker, Tobias OptHof
May 31, 2003·Journal of Cardiovascular Pharmacology·Giora AmitzurMichael Eldar
Aug 1, 1993·Pacing and Clinical Electrophysiology : PACE·K MizumakiT Misaki
Mar 1, 1993·Pacing and Clinical Electrophysiology : PACE·R A CooperR E Ideker
Nov 1, 1996·Pacing and Clinical Electrophysiology : PACE·A MichelucciG F Gensini
Aug 1, 1996·Pacing and Clinical Electrophysiology : PACE·S KimberI Parsons
Apr 1, 1997·Pacing and Clinical Electrophysiology : PACE·F A Ehlert, J J Goldberger
Nov 14, 1997·Pacing and Clinical Electrophysiology : PACE·M A Murda'hA J Camm
Feb 17, 1999·Pacing and Clinical Electrophysiology : PACE·V S PrakashS A Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Cardiac Electrophysiology

Cardiac electrophysiology is the study of electrical activities of the heart and includes the assessment, diagnosis, and treatment of cardiac events. Find the latest research on cardiac electrophysiology here.